Endocrine complications in long-term survivors of childhood cancers

被引：140

作者：

Chemaitilly, Wassim ^{[1
]}

Sklar, Charles A. ^{[2
]}

机构：

[1] UPMC, Childrens Hosp Pittsburgh, Dept Pediat, Div Endocrinol, Pittsburgh, PA 15224 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Pediat, New York, NY 10065 USA

来源：

关键词：

ACUTE LYMPHOBLASTIC-LEUKEMIA; BONE-MARROW-TRANSPLANTATION; TOTAL-BODY IRRADIATION; GROWTH-HORMONE TREATMENT; FUNCTION FOLLOWING CHEMOTHERAPY; IMPAIRED GLUCOSE-TOLERANCE; STEM-CELL TRANSPLANTATION; YOUNG-ADULT SURVIVORS; OVARIAN-FUNCTION; FINAL HEIGHT;

D O I：

10.1677/ERC-10-0002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Endocrine disturbances are among the most frequently reported complications in childhood cancer survivors, affecting between 20 and 50% of individuals who survive into adulthood. Most endocrine complications are the result of prior cancer treatments, especially radiotherapy. The objective of the present review is to discuss the main endocrine complications observed in this population, including disorders of the hypothalamic-pituitary axis, disorders of pubertal development, thyroid dysfunction, gonadal dysfunction, decreased bone mineral density, obesity, and alterations in glucose metabolism with a special focus on recent findings reported from the Childhood Cancer Survivor Study. Endocrine-Related Cancer (2010) 17 R141-R159

引用

页码：R141 / R159

页数：19

共 169 条

[1] Thyroid neoplasms after therapeutic radiation for malignancies during childhood or adolescence [J].

Acharya, S ;

Sarafoglou, K ;

LaQuaglia, M ;

Lindsley, S ;

Gerald, W ;

Wollner, N ;

Tan, C ;

Sklar, C .

CANCER, 2003, 97 (10) :2397-2403

[2]

Adan L, 2000, MED PEDIATR ONCOL, V34, P14, DOI 10.1002/(SICI)1096-911X(200001)34:1<14::AID-MPO3>3.3.CO

[3]

2-N

[4] Growth and endocrine function in children with acute myeloid leukaemia after bone marrow transplantation using busulfan/cyclophosphamide [J].

Afify, Z ;

Shaw, PJ ;

Clavano-Harding, A ;

Cowell, CT .

BONE MARROW TRANSPLANTATION, 2000, 25 (10) :1087-1092

[5] Bone mineral density in young adult survivors of childhood cancer [J].

Aisenberg, J ;

Kalaitzoglou, G ;

Whittam, E ;

Heller, G ;

Schneider, R ;

Sklar, C .

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 1998, 20 (03) :241-245

[6] Persistent altered spermatogenesis in long-term childhood cancer survivors [J].

Andreu, JAL ;

Fernández, PJ ;

Tortajada, JFI ;

Navarro, I ;

Rodríguez-Ineba, A ;

Antonio, P ;

Muro, MD ;

Romeu, A .

PEDIATRIC HEMATOLOGY AND ONCOLOGY, 2000, 17 (01) :21-30

[7]

[Anonymous], WILLIAMS TXB ENDOCRI

[8] Semen analysis following allogeneic bone marrow transplantation. Additional data for evidence-based counselling [J].

Anserini, P ;

Chiodi, S ;

Spinelli, S ;

Costa, M ;

Conte, N ;

Copello, F ;

Bacigalupo, A .

BONE MARROW TRANSPLANTATION, 2002, 30 (07) :447-451

[9] Chronic Health Conditions in Childhood Cancer Survivors: Is it All Treatment-Related-or Do Genetics Play a Role? [J].

Armenian, Saro H. ;

Bhatia, Smita .

JOURNAL OF GENERAL INTERNAL MEDICINE, 2009, 24 :395-400

[10] Abnormal Timing of Menarche in Survivors of Central Nervous System Tumors A Report From the Childhood Cancer Survivor Study [J].

Armstrong, Gregory T. ;

Whitton, John A. ;

Gajjar, Amar ;

Kun, Larry E. ;

Chow, Eric J. ;

Stovall, Marilyn ;

Leisenring, Wendy ;

Robison, Leslie L. ;

Sklar, Charles A. .

CANCER, 2009, 115 (11) :2562-2570

← 1 2 3 4 5 6 7 8 9 10 →