Effect of atorvastatin and fenofibrate on autonomic tone in subjects with combined hyperlipidemia

被引：30
|
作者：
Melenovsky, V
Wichterle, D
Simek, J
Malik, J
Haas, T
Ceska, R
Malik, M
机构：
[1] Charles Univ Prague, Dept Internal Med 3, Sch Med 1, Prague, Czech Republic
[2] Johns Hopkins Med Inst, Div Cardiol, Dept Med, Baltimore, MD 21205 USA
[3] St George Hosp, Sch Med, Dept Cardiol Sci, London, England
来源：
AMERICAN JOURNAL OF CARDIOLOGY | 2003年 / 92卷 / 03期
关键词：
D O I：
10.1016/S0002-9149(03)00643-X
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This randomized open-label trial investigated whether autonomic cardiovascular control is altered in middle-aged men with combined hyperlipidemia and whether such alterations are affected by short-term, lipid-lowering therapy with atorvastatin and/or fenofibrate. Compared with normolipidemic subjects, untreated subjects with combined hyperlipidemia had several abnormalities of autonomic tone, indicating increased sympathetic tone and decreased baroreflex sensitivity. The alterations in autonomic cardiovascular control were partially reversible by each of the lipid-lowering drugs. (C) 2003 by Excerpta Medica, Inc.
引用
收藏
页码：337 / 341
页数：5
相关论文
共 50 条
  • [41] Effects of low doses of atorvastatin in patients with familial combined hyperlipidemia
    Bottazzo, S
    Severi, G
    Fazzin, G
    ATHEROSCLEROSIS, 1998, 138 : S8 - S8
  • [42] Fenofibrate, but not atorvastatin treatment increases homocystein levels in patients with combined hyperlipidaemia
    Melenovsky, V
    Malik, J
    Wichterle, D
    Simek, J
    Ceska, R
    Parizkova, A
    EUROPEAN HEART JOURNAL, 2000, 21 : 636 - 636
  • [43] Effect of atorvastatin and bezafibrate on plasma levels of C-reactive protein in combined (mixed) hyperlipidemia
    Gómez-Gerique, JA
    Ros, E
    Oliván, J
    Mostaza, JM
    Vilardell, M
    Pintó, X
    Civeira, F
    Hernández, A
    da Silva, PM
    Rodriguez-Botaro, A
    Zambón, D
    Lima, J
    Díaz, C
    Aristegui, R
    Sol, JM
    Chaves, J
    Hernández, G
    ATHEROSCLEROSIS, 2002, 162 (02) : 245 - 251
  • [44] ATROPINE AND ELECTROPHORETIC TEST OF AUTONOMIC TONE IN HEALTHY SUBJECTS
    ZAPLETALEK, M
    TABARKA, K
    ACTIVITAS NERVOSA SUPERIOR, 1969, 11 (04): : 303 - +
  • [45] EFFECTS OF ATORVASTATIN-FENOFIBRATE COMBINATION COMPARED TO ATORVASTATIN MONOTHERAPY ON LIPID PROFILE IN PATIENTS WITH COMBINED DYSLIPIDEMIA
    Derosa, G.
    Salvadeo, S.
    Ferrari, I.
    Cicero, A.
    ATHEROSCLEROSIS SUPPLEMENTS, 2009, 10 (02)
  • [46] Leptin levels in subjects with familial combined hyperlipidemia
    van der Vleuten, GM
    Veerkamp, MJ
    van Tits, LJ
    Toenhake, H
    den Heijer, M
    Stalenhoef, AF
    de Graaf, J
    CIRCULATION, 2003, 108 (17) : 743 - 743
  • [47] Effects of atorvastatin, simvastatin, and fenofibrate therapy on monocyte chemoattractant protein-1 secretion in patients with hyperlipidemia
    Kowalski, J
    Okopien, B
    Madej, A
    Zielinski, M
    Belowski, D
    Kalina, Z
    Herman, ZS
    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2003, 59 (03) : 189 - 193
  • [48] Effects of atorvastatin, simvastatin, and fenofibrate therapy on monocyte chemoattractant protein-1 secretion in patients with hyperlipidemia
    J. Kowalski
    B. Okopień
    A. Madej
    M. Zieliński
    D. Belowski
    Z. Kalina
    Z. S. Herman
    European Journal of Clinical Pharmacology, 2003, 59 : 189 - 193
  • [49] Leptin levels in subjects with familial combined hyperlipidemia
    van der Vleuten, G
    Veerkamp, M
    van Tits, L
    Toenhake, H
    den Heijer, M
    Stalenhoef, A
    de Graaf, J
    ATHEROSCLEROSIS SUPPLEMENTS, 2004, 5 (01) : 34 - 35
  • [50] Plasma homocysteine in subjects with familial combined hyperlipidemia
    Veerkamp, MJ
    de Graaf, J
    den Heijer, M
    Blom, HJ
    Stalenhoef, AFH
    ATHEROSCLEROSIS, 2003, 166 (01) : 111 - 117
12345