Effect of atorvastatin and fenofibrate on autonomic tone in subjects with combined hyperlipidemia

被引：30
|
作者：
Melenovsky, V
Wichterle, D
Simek, J
Malik, J
Haas, T
Ceska, R
Malik, M
机构：
[1] Charles Univ Prague, Dept Internal Med 3, Sch Med 1, Prague, Czech Republic
[2] Johns Hopkins Med Inst, Div Cardiol, Dept Med, Baltimore, MD 21205 USA
[3] St George Hosp, Sch Med, Dept Cardiol Sci, London, England
来源：
AMERICAN JOURNAL OF CARDIOLOGY | 2003年 / 92卷 / 03期
关键词：
D O I：
10.1016/S0002-9149(03)00643-X
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This randomized open-label trial investigated whether autonomic cardiovascular control is altered in middle-aged men with combined hyperlipidemia and whether such alterations are affected by short-term, lipid-lowering therapy with atorvastatin and/or fenofibrate. Compared with normolipidemic subjects, untreated subjects with combined hyperlipidemia had several abnormalities of autonomic tone, indicating increased sympathetic tone and decreased baroreflex sensitivity. The alterations in autonomic cardiovascular control were partially reversible by each of the lipid-lowering drugs. (C) 2003 by Excerpta Medica, Inc.
引用
收藏
页码：337 / 341
页数：5
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