Mouse duplicate genes are as essential as singletons

被引：91

作者：

Liao, Ben-Yang ^{[1
]}

Zhang, Jianzhi ^{[1
]}

机构：

[1] Univ Michigan, Dept Ecol & Evolutionary Biol, Ann Arbor, MI 48109 USA

来源：

TRENDS IN GENETICS | 2007年 / 23卷 / 08期

关键词：

D O I：

10.1016/j.tig.2007.05.006

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Duplicate genes in mouse are widely thought to have functional redundancy, and to be less essential than singleton genes. We analyzed nearly 3900 individually knocked out mouse genes and discovered that the proportion of essential genes is similar to 55% in both singletons and duplicates. This suggests that mammalian duplicates rarely compensate for each other, and that the absence of phenotypes in mice deficient for a duplicate gene should not be automatically attributed to paralogous compensation.

引用

页码：378 / 381

页数：4

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