Isostructural metabolites of two anti-Parkinson drugs

被引：2
|
作者：
Simon, K
Harmat, V
Torok, Z
Bocskei, Z
Hermecz, I
机构：
[1] Chinoin Chem & Pharmaceut Works Ltd, Dept Preclin Dev, H-1325 Budapest, Hungary
[2] Eotvos Lorand Univ, Dept Theoret Chem, H-1518 Budapest, Hungary
来源：
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY | 1998年 / 54卷
关键词：
D O I：
10.1107/S0108270197019896
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The absolute configurations of desmethylselegiline hydrochloride [(R)-(-)-1-benzyl-N-(2-propynyl)ethylammonium chloride, C12H16N+.Cl-], (1), and p-fluorodesmethylselegiline hydrochloride [(R)-(-)-1-(4-fluorobenzyl)-N-(2-propynyl)ethylammonium chloride, C12H15FN+.Cl-], (2), have been determined. The two compounds are metabolites of the anti-Parkinson agent selegiline and its backup, p-fluoroselegiline. The two crystal structures are highly isostructural.
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页码：811 / 813
页数：3
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