Effects of a Platelet Gel on Early Graft Revascularization after Anterior Cruciate Ligament Reconstruction: A Prospective, Randomized, Double-Blind, Clinical Trial

被引:87
作者
Vogrin, M. [1 ]
Rupreht, M. [1 ]
Dinevski, D. [2 ]
Haspl, M. [4 ]
Kuhta, M. [1 ]
Jevsek, M. [1 ]
Knezevic, M. [3 ]
Rozman, P. [3 ]
机构
[1] Univ Hosp Maribor, Dept Orthoped Surg, SI-2000 Maribor, Slovenia
[2] Univ Maribor, Fac Med, SLO-2000 Maribor, Slovenia
[3] Blood Transfus Ctr Slovenia, Ljubljana, Slovenia
[4] Special Hosp Orthoped Surg Akrom, Krapinske Toplice, Croatia
关键词
Anterior cruciate ligament reconstruction; Hamstring graft; Platelet-derived growth factors; Platelet gel; Revascularization; MEDIAL COLLATERAL LIGAMENT; GROWTH FACTOR-BB; PATELLAR TENDON; FOLLOW-UP; HAMSTRING TENDONS; 2-YEAR; MRI;
D O I
10.1159/000318597
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background: Slow graft healing in bone tunnels and a slow graft ligamentization process after anterior cruciate ligament (ACL) reconstruction are some of the reasons for prolonged rehabilitation. Aims: The purpose of this study was to determine if the use of platelet gel (PG) accelerates early graft revascularization after ACL reconstruction. Methods: PG was produced from autologous platelet-rich plasma and applied locally. We quantitatively evaluated the revascularization process in the osteoligamentous interface zone in the bone tunnels and in the intra-articular part of the graft by means of contrast-enhanced magnetic resonance imaging (MRI). Results: After 4-6 weeks, the PG-treated group demonstrated a significantly higher level of vascularization in the osteoligamentous interface (0.33 +/- 0.09) than the control group (0.16 +/- 0.09, p < 0.001). In the intra-articular part of the graft, we found no evidence of revascularization in either group. Conclusion: Locally applied PG enhanced early revascularization of the graft in the osteoligamentous interface zone after ACL reconstruction. Copyright (C) 2010 S. Karger AG, Basel
引用
收藏
页码:77 / 85
页数:9
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