Sigma Receptor (σR) Ligands with Antiproliferative and Anticancer Activity

被引：43
作者：
Georgiadis, Markos-Orestis [1 ]
Karoutzou, Olga [1 ]
Foscolos, Angeliki-Sofia [1 ]
Papanastasiou, Ioannis [1 ]
机构：
[1] Natl & Kapodistrian Univ Athens, Div Pharmaceut Chem, Dept Pharm, Sch Hlth Sci, Athens 15784, Greece
来源：
MOLECULES | 2017年 / 22卷 / 09期
关键词：
sigma 1 receptor antagonist; sigma 2 receptor agonist; antiproliferative activity; anticancer activity; radiolabeled and fluorescent probes; biomarkers; STRUCTURE-AFFINITY RELATIONSHIP; IN-VITRO BINDING; TUMOR-CELL DEATH; CANCER-CELLS; PHENYLCARBAMATE ANALOGS; SUBNANOMOLAR AFFINITY; BENZAMIDE ANALOGS; BREAST-CANCER; DERIVATIVES; BRAIN;
D O I：
10.3390/molecules22091408
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sigma receptor (sigma R) ligands have proven to be useful as cancer diagnostics and anticancer therapeutics and their ligands have been developed as molecular probes in oncology. Moreover, various sigma R ligands generate cancer cell death in vitro and in vivo. These sigma R ligands have exhibited promising results against numerous human and rodent cancers and are investigated under preclinical and clinical study trials, indicating a new category of drugs in cancer therapy.
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页数：18
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