Control of the Ralstonia solanacearum Type III secretion system (Hrp) genes by the global virulence regulator PhcA

被引：81

作者：

Genin, S

Brito, B

Denny, TP

Boucher, C

机构：

[1] INRA, CNRS, Lab Interact Plantes Microorganismes, UMR 2594, F-31326 Castanet Tolosan, France

[2] Univ Georgia, Dept Plant Pathol, Athens, GA 30602 USA

来源：

FEBS LETTERS | 2005年 / 579卷 / 10期

关键词：

quorum-sensing; regulation; pathogenicity; bacterial wilt disease; hypersensitive response;

D O I：

10.1016/j.febslet.2005.02.058

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Expression of several virulence factors in the plant pathogen bacterium Ralstonia solanacearum is controlled by a complex regulatory network, at the center of which is PhcA. We provide genetic evidence that PhcA also represses the expression of hrp genes that code for the Type III protein secretion system, a major pathogenicity determinant in this bacterium. The repression of hrp genes in complete medium is relieved in a phcA mutant and two distinct signals, a quorum-sensing signal and complex nitrogen sources, appear to trigger this PhcA-dependent repression. This control of hrp gene expression by PhcA is realized at the level of the HrpG regulatory protein. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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页码：2077 / 2081

页数：5

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