Bone Morphogenetic Protein Signaling in Cancer; Some Topics in the Recent 10 Years

被引：40

作者：

Ehata, Shogo ^{[1
]}

Miyazono, Kohei ^{[2
]}

机构：

[1] Wakayama Med Univ, Sch Med, Dept Pathol, Wakayama, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Appl Pathol, Tokyo, Japan

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2022年 / 10卷

关键词：

BMPs; ALKs; Smads; cancer; metastasis; angiogeneis; RECEPTOR-LIKE KINASE-1; HUMAN MONOCLONAL-ANTIBODY; SQUAMOUS-CELL CARCINOMA; OVARIAN-CANCER; STEM-CELLS; HEPATOCELLULAR-CARCINOMA; MESENCHYMAL TRANSITION; PHASE-I; SUPPRESSES METASTASIS; THERAPEUTIC TARGET;

D O I：

10.3389/fcell.2022.883523

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF-beta) family, are multifunctional cytokines. BMPs have a broad range of functions, and abnormalities in BMP signaling pathways are involved in cancer progression. BMPs activate the proliferation of certain cancer cells. Malignant phenotypes of cancer cells, such as increased motility, invasiveness, and stemness, are enhanced by BMPs. Simultaneously, BMPs act on various cellular components and regulate angiogenesis in the tumor microenvironment. Thus, BMPs function as pro-tumorigenic factors in various types of cancer. However, similar to TGF-beta, which shows both positive and negative effects on tumorigenesis, BMPs also act as tumor suppressors in other types of cancers. In this article, we review important findings published in the recent decade and summarize the pro-oncogenic functions of BMPs and their underlying mechanisms. The current status of BMP-targeted therapies for cancers is also discussed.

引用

页数：14

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