Bone Morphogenetic Protein Signaling in Cancer; Some Topics in the Recent 10 Years

被引：40

作者：

Ehata, Shogo ^{[1
]}

Miyazono, Kohei ^{[2
]}

机构：

[1] Wakayama Med Univ, Sch Med, Dept Pathol, Wakayama, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Appl Pathol, Tokyo, Japan

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2022年 / 10卷

关键词：

BMPs; ALKs; Smads; cancer; metastasis; angiogeneis; RECEPTOR-LIKE KINASE-1; HUMAN MONOCLONAL-ANTIBODY; SQUAMOUS-CELL CARCINOMA; OVARIAN-CANCER; STEM-CELLS; HEPATOCELLULAR-CARCINOMA; MESENCHYMAL TRANSITION; PHASE-I; SUPPRESSES METASTASIS; THERAPEUTIC TARGET;

D O I：

10.3389/fcell.2022.883523

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF-beta) family, are multifunctional cytokines. BMPs have a broad range of functions, and abnormalities in BMP signaling pathways are involved in cancer progression. BMPs activate the proliferation of certain cancer cells. Malignant phenotypes of cancer cells, such as increased motility, invasiveness, and stemness, are enhanced by BMPs. Simultaneously, BMPs act on various cellular components and regulate angiogenesis in the tumor microenvironment. Thus, BMPs function as pro-tumorigenic factors in various types of cancer. However, similar to TGF-beta, which shows both positive and negative effects on tumorigenesis, BMPs also act as tumor suppressors in other types of cancers. In this article, we review important findings published in the recent decade and summarize the pro-oncogenic functions of BMPs and their underlying mechanisms. The current status of BMP-targeted therapies for cancers is also discussed.

引用

页数：14

共 160 条

[1] A Phase Ib, Open-Label Study of Dalantercept, an Activin Receptor-Like Kinase 1 Ligand Trap, plus Sorafenib in Advanced Hepatocellular Carcinoma [J].

Abou-Alfa, Ghassan K. ;

Miksad, Rebecca A. ;

Tejani, Mohamedtaki A. ;

Williamson, Stephen ;

Gutierrez, Martin E. ;

Olowokure, Olugbenga O. ;

Sharma, Manish R. ;

El Dika, Imane ;

Sherman, Matthew L. ;

Pandya, Shuchi S. .

ONCOLOGIST, 2019, 24 (02) :161-+

[2] Differential cellular responses induced by dorsomorphin and LDN-193189 in chemotherapy-sensitive and chemotherapy-resistant human epithelial ovarian cancer cells [J].

Ali, Jennifer L. ;

Lagasse, Brittany J. ;

Minuk, Ainsley J. ;

Love, Allison J. ;

Moraya, Amani I. ;

Lam, Linda ;

Arthur, Gilbert ;

Gibson, Spencer B. ;

Morrison, Ludivine Coudiere ;

Werbowetski-Ogilvie, Tamra E. ;

Fu, Yangxin ;

Nachtigal, Mark W. .

INTERNATIONAL JOURNAL OF CANCER, 2015, 136 (05) :E455-E469

[3] Uncovering Molecular Bases Underlying Bone Morphogenetic Protein Receptor Inhibitor Selectivity [J].

Alsamarah, Abdelaziz ;

LaCuran, Alecander E. ;

Oelschlaeger, Peter ;

Hao, Jijun ;

Luo, Yun .

PLOS ONE, 2015, 10 (07)

[4] Anti-Mullerian hormone inhibits growth of AMH type II receptor-positive human ovarian granulosa cell tumor cells by activating apoptosis [J].

Anttonen, Mikko ;

Farkkila, Anniina ;

Tauriala, Hanna ;

Kauppinen, Marjut ;

MacLaughlin, David T. ;

Unkila-Kallio, Leila ;

Butzow, Ralf ;

Heikinheimo, Markku .

LABORATORY INVESTIGATION, 2011, 91 (11) :1605-1614

[5] BMP4 Upregulation Is Associated with Acquired Drug Resistance and Fatty Acid Metabolism in EGFR-Mutant Non-Small-Cell Lung Cancer Cells [J].

Bach, Duc-Hiep ;

Thi-Thu-Trang Luu ;

Kim, Donghwa ;

An, Yong Jin ;

Park, Sunghyouk ;

Park, Hyen Joo ;

Lee, Sang Kook .

MOLECULAR THERAPY-NUCLEIC ACIDS, 2018, 12 :817-828

[6] ΔNp63α-Mediated Activation of Bone Morphogenetic Protein Signaling Governs Stem Cell Activity and Plasticity in Normal and Malignant Mammary Epithelial Cells [J].

Balboni, Amanda L. ;

Hutchinson, Justine A. ;

DeCastro, Andrew J. ;

Cherukuri, Pratima ;

Liby, Karen ;

Sporn, Michael B. ;

Schwartz, Gary N. ;

Wells, Wendy A. ;

Sempere, Lorenzo F. ;

Yu, Paul B. ;

DiRenzo, James .

CANCER RESEARCH, 2013, 73 (02) :1020-1030

[7] BMP4, a strong better prognosis predictor, has a subtype preference and cell development association in gliomas [J].

Bao, Zhaoshi ;

Zhang, Chuanbao ;

Yan, Wei ;

Liu, Yanwei ;

Li, Mingyang ;

Zhang, Wei ;

Jiang, Tao .

JOURNAL OF TRANSLATIONAL MEDICINE, 2013, 11

[8] Safety, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of Dalantercept, an Activin Receptor-like Kinase-1 Ligand Trap, in Patients with Advanced Cancer [J].

Bendell, Johanna C. ;

Gordon, Michael S. ;

Hurwitz, Herbert I. ;

Jones, Suzanne F. ;

Mendelson, David S. ;

Blobe, Gerard C. ;

Agarwal, Neeraj ;

Condon, Carolyn H. ;

Wilson, Dawn ;

Pearsall, Amelia E. ;

Yang, Yijun ;

McClure, Ty ;

Attie, Kenneth M. ;

Sherman, Matthew L. ;

Sharma, Sunil .

CLINICAL CANCER RESEARCH, 2014, 20 (02) :480-489

[9] BMP signalling: agony and antagony in the family [J].

Brazil, Derek P. ;

Church, Rachel H. ;

Surae, Satnam ;

Godson, Catherine ;

Martin, Finian .

TRENDS IN CELL BIOLOGY, 2015, 25 (05) :249-264

[10] Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations [J].

Buczkowicz, Pawel ;

Hoeman, Christine ;

Rakopoulos, Patricia ;

Pajovic, Sanja ;

Letourneau, Louis ;

Dzamba, Misko ;

Morrison, Andrew ;

Lewis, Peter ;

Bouffet, Eric ;

Bartels, Ute ;

Zuccaro, Jennifer ;

Agnihotri, Sameer ;

Rya, Scott ;

Barszczyk, Mark ;

Chornenkyy, Yevgen ;

Bourgey, Mathieu ;

Bourque, Guillaume ;

Montpetit, Alexandre ;

Cordero, Francisco ;

Castelo-Branco, Pedro ;

Mangere, Joshua ;

Tabori, Uri ;

Ching, King ;

Huang, Annie ;

Taylor, Kathryn R. ;

Mackay, Alan ;

Bendell, Anne E. ;

Nazarian, Javad ;

Fangusaro, Jason R. ;

Karajannis, Matthias A. ;

Zagzag, David ;

Foreman, Nicholas K. ;

Donson, Andrew ;

Hegert, Julia V. ;

Smith, Amy ;

Chan, Jennifer ;

Lafay-Cousin, Lucy ;

Dunn, Sandra ;

Hukin, Juliette ;

Dunham, Chris ;

Scheinemann, Katrin ;

Michaud, Jean ;

Zelcer, Shayna ;

Ramsay, David ;

Cain, Jason ;

Brennan, Cameron ;

Souweidane, Mark M. ;

Jones, Chris ;

Allis, C. David ;

Brudno, Michael .

NATURE GENETICS, 2014, 46 (05) :451-456

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