Standardized Postnatal Management of Infants with Congenital Diaphragmatic Hernia in Europe: The CDH EURO Consortium Consensus-2015 Update

被引：375

作者：

Snoek, Kitty G. ^{[1
]}

Reiss, Irwin K. M. ^{[1
]}

Greenough, Anne ^{[3
]}

Capolupo, Irma ^{[5
]}

Urlesberger, Berndt ^{[6
]}

Wessel, Lucas ^{[7
]}

Storme, Laurent ^{[8
]}

Deprest, Jan ^{[4
,9
]}

Schaible, Thomas ^{[7
]}

van Heijst, Arno ^{[2
]}

Tibboel, Dick ^{[1
]}

机构：

[1] Univ Med Ctr Rotterdam, Erasmus MC Sophia Childrens Hosp, Rotterdam, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Nijmegen, Netherlands

[3] Kings Coll London, London WC2R 2LS, England

[4] Univ Coll London Hosp, London, England

[5] Bambino Gesu Pediat Hosp, Rome, Italy

[6] Med Univ Graz, Graz, Austria

[7] Univ Klinikum Mannheim, Mannheim, Germany

[8] Hop Jeanne de Flandre, Lille, France

[9] Univ Hosp KU Leuven, Leuven, Belgium

来源：

NEONATOLOGY | 2016年 / 110卷 / 01期

关键词：

Congenital diaphragmatic hernia; Standardized treatment; Consensus; EXTRACORPOREAL MEMBRANE-OXYGENATION; PERSISTENT PULMONARY-HYPERTENSION; ANTIREFLUX SURGERY; NEWBORN-INFANTS; CASE VOLUME; REPAIR; RESUSCITATION; PREMEDICATION; OUTCOMES; HYPERCAPNIA;

D O I：

10.1159/000444210

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

In 2010, the congenital diaphragmatic hernia (CDH) EURO Consortium published a standardized neonatal treatment protocol. Five years later, the number of participating centers has been raised from 13 to 22. In this article the relevant literature is updated, and consensus has been reached between the members of the CDH EURO Consortium. Key updated recommendations are: (1) planned delivery after a gestational age of 39 weeks in a high-volume tertiary center; (2) neuromuscular blocking agents to be avoided during initial treatment in the delivery room; (3) adapt treatment to reach a preductal saturation of between 80 and 95% and postductal saturation >70%; (4) target PaCO2 to be between 50 and 70 mm Hg; (5) conventional mechanical ventilation to be the optimal initial ventilation strategy, and (6) intravenous sildenafil to be considered in CDH patients with severe pulmonary hypertension. This article represents the current opinion of all consortium members in Europe for the optimal neonatal treatment of CDH. (C) 2016 The Author(s) Published by S. Karger AG, Basel

引用

页码：66 / 74

页数：9