Conceptualizing Biological Aging and Frailty in Orthopaedics A Framework for Clinical Practice

被引：6

作者：

Cong, Ting ^{[1
,2
]}

Hall, Arielle J. ^{[1
,3
]}

Jia, Zhimeng ^{[1
,4
]}

Christiano, Anthony ^{[1
,5
]}

Elsevier, Hannah C. K. ^{[1
,6
]}

Cheung, Zoe B. ^{[1
,7
]}

Wellman, David ^{[1
,8
]}

Forsh, David ^{[1
,2
]}

Lane, Joseph M. ^{[1
,9
]}

机构：

[1] Mt Sinai Hosp, New York, NY 10029 USA

[2] Mt Sinai Hosp, Dept Orthopaed Surg, New York, NY 10029 USA

[3] Rowan Sch Osteopath Med, Stratford, NJ USA

[4] Mt Sinai Hosp, Temmy Latner Ctr Palliat Care, Toronto, ON M5G 1X5, Canada

[5] Hennepin Healthcare, Dept Orthopaed Surg, Minneapolis, MN USA

[6] Univ Calif San Francisco, Dept Orthopaed Surg, San Francisco, CA USA

[7] Univ Calif Davis, Dept Orthopaed Surg, Davis, CA 95616 USA

[8] Westchester Med Ctr, Dept Orthopaed Surg, Westchester, NY USA

[9] Hosp Special Surg, Dept Orthopaed Surg, 535 E 70th St, New York, NY 10021 USA

来源：

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME | 2022年 / 104卷 / 13期

关键词：

HIP FRACTURE; FRAGILITY FRACTURES; ELDERLY-PATIENTS; SOCIAL-ISOLATION; OLDER-ADULTS; MORTALITY; DISABILITY; INDEX; RISK; HOSPITALIZATION;

D O I：

10.2106/JBJS.21.01053

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

& x27a4; Biological aging can best be conceptualized clinically as a combination of 3 components: frailty, comorbidity, and disability. & x27a4; Despite advancements in the understanding of senescence, chronological age remains the best estimate of biological age. However, a useful exercise for practitioners is to look beyond chronological age in clinical and surgical decision-making. & x27a4; A chronologically aging person does not age biologically at the same rate. & x27a4; The best way to understand frailty is to consider it as a physical phenotype. & x27a4; Physical optimization should parallel medical optimization before elective surgery. & x27a4; The poorer the host (both in terms of bone quality and propensity for healing), the more robust the implant construct must be to minimize reliance on host biology.

引用

页码：1212 / 1222

页数：11

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