Murine gammaherpesvirus 68 open reading frame 11 encodes a nonessential virion component

被引：13

作者：

Boname, JM ^{[1
]}

May, JS ^{[1
]}

Stevenson, PG ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pathol, Div Virol, Cambridge CB2 1QP, England

来源：

JOURNAL OF VIROLOGY | 2005年 / 79卷 / 05期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1128/JVI.79.5.3163-3168.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Open reading frame 11 (ORF11) is a conserved gammaherpesvirus gene that remains undefined. We identified the product of murine gammaherpesvirus 68 (MHV-68) ORF11, p43, as a virion component with a predominantly perinuclear distribution in infected cells. MHV-68 lacking p43 grew normally in vitro but showed reduced lytic replication in vivo and a delay in seeding to the spleen. Subsequent latency amplification was normal. Thus, MHV-68 ORF11 encoded a virion component that was important for in vivo lytic replication but dispensable for the establishment of latency.

引用

页码：3163 / 3168

页数：6

共 16 条

[1] Cloning and mutagenesis of the murine gammaherpesvirus 68 genome as an infectious bacterial artificial chromosome [J].

Adler, H ;

Messerle, M ;

Wagner, M ;

Koszinowski, UH .

JOURNAL OF VIROLOGY, 2000, 74 (15) :6964-6974

[2] Gammaherpesvirus lytic gene expression as characterized by DNA array [J].

Ahn, JW ;

Powell, KL ;

Kellam, P ;

Alber, DG .

JOURNAL OF VIROLOGY, 2002, 76 (12) :6244-6256

[3]

BLASKOVIC D, 1980, ACTA VIROL, V24, P468

[4] Murine gammaherpesvirus 68 lacking thyraidine kinase shows severe attenuation of lytic cycle replication in vivo but still establishes latency [J].

Coleman, HM ;

de Lima, B ;

Morton, V ;

Stevenson, PG .

JOURNAL OF VIROLOGY, 2003, 77 (04) :2410-2417

[5] Murine gammaherpesvirus 68 lacking gp150 shows defective virion release but establishes normal latency in vivo [J].

De Lima, BD ;

May, JS ;

Stevenson, PG .

JOURNAL OF VIROLOGY, 2004, 78 (10) :5103-5112

[6] Transcriptome profile of murine gammaherpesvirus-68 lytic infection [J].

Ebrahimi, B ;

Dutia, BM ;

Roberts, KL ;

Garcia-Ramirez, JJ ;

Dickinson, P ;

Stewart, JP ;

Ghazal, P ;

Roy, DJ ;

Nash, AA .

JOURNAL OF GENERAL VIROLOGY, 2003, 84 :99-109

[7] CLONING AND MOLECULAR CHARACTERIZATION OF THE MURINE HERPESVIRUS 68 GENOME [J].

EFSTATHIOU, S ;

HO, YM ;

MINSON, AC .

JOURNAL OF GENERAL VIROLOGY, 1990, 71 :1355-1364

[8] Kaposi's sarcoma-associated herpesvirus latent and lytic gene expression as revealed by DNA arrays [J].

Jenner, RG ;

Albà, MM ;

Boshoff, C ;

Kellam, P .

JOURNAL OF VIROLOGY, 2001, 75 (02) :891-902

[9] Characterization of murine gammaherpesvirus 68 glycoprotein B [J].

Lopes, FB ;

Colaco, S ;

May, JS ;

Stevenson, PG .

JOURNAL OF VIROLOGY, 2004, 78 (23) :13370-13375

[10] Transcription program of murine gammaherpesvirus 68 [J].

Martinez-Guzman, D ;

Rickabaugh, T ;

Wu, TT ;

Brown, H ;

Cole, S ;

Song, MJ ;

Tong, LM ;

Sun, R .

JOURNAL OF VIROLOGY, 2003, 77 (19) :10488-10503

← 1 2 →