A lysozyme corona complex for the controlled pharmacokinetic release of probucol from mesoporous silica particles

被引：4
|
作者：
Giri, Kalpeshkumar [1 ,2 ]
Lau, Michael [1 ]
Kuschnerus, Inga [1 ,2 ]
Moroni, Irene [1 ]
Garcia-Bennett, Alfonso E. [1 ,2 ]
机构：
[1] Macquarie Univ, Dept Mol Sci, Sydney, NSW, Australia
[2] Macquarie Univ, Ctr Nanoscale & BioPhoton, Sydney, NSW, Australia
来源：
BIOMATERIALS SCIENCE | 2020年 / 8卷 / 14期
关键词：
BIOAVAILABILITY; NANOPARTICLES; ADSORPTION; MOLECULES; PLATFORM; SBA-15;
D O I：
10.1039/d0bm00445f
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Mesoporous silica particles (MSPs) enhance the release kinetics of poorly soluble compound probucol (PB) under the influence of a pore-blocking protein corona, prepared with lysozyme protein adsorption.In vivooral administration experiments show a prolongation in the time to reach maximum systemic concentration and half-life of PB released from the lysozyme-MSP complex in comparison to the MSP alone. Specific hard protein corona complexes can act as functional diffusion barriers for the controlled release of drugs from MSP based formulations.
引用
收藏
页码：3800 / 3803
页数：4
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