Increased levels of adipokines in bipolar disorder

被引：72
作者：
Barbosa, Izabela Guimaraes [2 ]
Rocha, Natalia Pessoa [2 ]
de Miranda, Aline Silva
da Silva Magalhaes, Pedro Vieira [3 ,4 ]
Huguet, Rodrigo Barreto
de Souza, Lirlandia Pires
Kapczinski, Flavio [3 ,4 ]
Teixeira, Antonio Lucio [1 ,2 ]
机构：
[1] Univ Fed Minas Gerais, Inst Ciencias Biol, Lab Imunofarmacol, Dept Bioquim & Imunol, BR-31270901 Belo Horizonte, MG, Brazil
[2] Univ Fed Minas Gerais, Programa Posgrad & Neurociencias, BR-31270901 Belo Horizonte, MG, Brazil
[3] Univ Fed Rio Grande do Sul, Mol Psychiat Lab, Porto Alegre, RS, Brazil
[4] Univ Fed Rio Grande do Sul, INCT Translat Med, Hosp Clin Porto Alegre HCPA, Porto Alegre, RS, Brazil
来源：
JOURNAL OF PSYCHIATRIC RESEARCH | 2012年 / 46卷 / 03期
关键词：
Bipolar disorder; Obesity; Adipokines; Inflammation; Biomarkers; SERUM LEPTIN LEVELS; METABOLIC SYNDROME; CHOLESTEROL LEVELS; PLASMA-LEVELS; ADIPONECTIN; OVERWEIGHT; INFLAMMATION; OBESITY; WEIGHT; COMORBIDITY;
D O I：
10.1016/j.jpsychires.2011.11.010
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Bipolar disorder (BD) is associated with considerable higher chronic medical comorbidities, overweight and obesity. Adipokines are adipocyte-derived secretory factors which have functions in immune response and seem to be associated with both BD and overweight. The aim of this study was to evaluate the plasma levels of adipokines (adiponectin, resistin and leptin) and TNF-alpha and its receptors (sTNFR1 and sTNFR2) in BD overweight patients in comparison with overweight controls. Thirty euthymic BD type-I patients and thirty controls matched by age, gender and body-mass index (BMI) were assessed by Mini-International Neuropsychiatric Interview, Young Mania and Hamilton Depression rating scales (YMRS and HDRS, respectively). Plasma levels of adiponectin, resistin, leptin, TNF-alpha and its soluble receptors were measured by ELISA. BD patients presented increased plasma levels of adiponectin (p < 0.001), leptin (p < 0.001) and sTNFR1 (p = 0.01). Plasma levels of adipokines were not correlated neither with clinical parameters nor TNF-alpha, sTNFR1 and sTNFR2 plasma levels. This study provides further support to the hypothesis of the immune/inflammatory imbalance in BD. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：389 / 393
页数：5
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