Synthesis and biology of new thyrotropin-releasing hormone (TRH) analogues

被引：28
|
作者：
Jain, R
Singh, J
Perlman, JH
Gershengorn, MC
机构：
[1] Natl Inst Pharmaceut Educ & Res, Dept Med Chem, SAS Nagar 160062, Punjab, India
[2] Cornell Univ, Weill Med Coll, Dept Med, Div Mol Med, New York, NY 10021 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 01期
关键词：
D O I：
10.1016/S0968-0896(01)00265-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We report synthesis and biological activities of several thyrotropin-releasing hormone (TRH) analogues in which the N-terminal pyroglutamic acid residue has been replaced with various carboxylic acids and the central histidine is modified with substituted-imidazole derivatives. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：189 / 194
页数：6
相关论文
共 50 条
  • [1] Synthesis and biological activity of thyrotropin-releasing hormone (TRH) analogues
    Deep, V.
    Kumar, S.
    Sharma, S. S.
    Jain, R.
    BIOPOLYMERS, 2007, 88 (04) : 533 - 533
  • [2] Synthesis, Receptor Binding, and CNS Pharmacological Studies of New Thyrotropin-Releasing Hormone (TRH) Analogues
    Monga, Vikramdeep
    Meena, Chhuttan L.
    Rajput, Satyendra
    Pawar, Chandrashekhar
    Sharma, Shyam S.
    Lu, Xinping
    Gershengorn, Marvin C.
    Jain, Rahul
    CHEMMEDCHEM, 2011, 6 (03) : 531 - 543
  • [3] Chemistry and Biology of Thyrotropin-Releasing Hormone (TRH) and its Analogs
    Monga, Vikramdeep
    Meena, Chhuttan L.
    Kaur, Navneet
    Jain, Rahul
    CURRENT MEDICINAL CHEMISTRY, 2008, 15 (26) : 2718 - 2733
  • [4] Synthesis and biology of ring-modified L-Histidine containing thyrotropin-releasing hormone (TRH) analogues
    Meena, Chhuttan L.
    Thakur, Avinash
    Nandekar, Prajwal P.
    Sharma, Shyam S.
    Sangamwar, Abhay T.
    Jain, Rahul
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 111 : 72 - 83
  • [5] Thyrotropin-releasing hormone (TRH) in the cerebellum
    Nobuyuki Shibusawa
    Koshi Hashimoto
    Masanobu Yamada
    The Cerebellum, 2008, 7
  • [6] Thyrotropin-releasing hormone (TRH) in the cerebellum
    Shibusawa, Nobuyuki
    Hashimoto, Koshi
    Yamada, Masanobu
    CEREBELLUM, 2008, 7 (01): : 84 - 95
  • [7] Thyrotropin-releasing hormone (TRH) analogues that exhibit selectivity to TRH receptor subtype 2
    Kaur, N
    Lu, XP
    Gershengorn, MC
    Jain, R
    JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (19) : 6162 - 6165
  • [8] SIGNIFICANCE OF HISTIDINE IN THYROTROPIN-RELEASING HORMONE (TRH)
    GILLESSEN, D
    PIVA, F
    STEINER, H
    STUDER, RO
    HELVETICA CHIMICA ACTA, 1971, 54 (05) : 1335 - +
  • [9] ENZYMATIC-SYNTHESIS OF THYROTROPIN-RELEASING HORMONE (TRH) BY HYPOTHALAMIC TRH SYNTHETASE
    MITNICK, M
    REICHLIN, S
    ENDOCRINOLOGY, 1972, 91 (05) : 1145 - &
  • [10] STUDIES ON INACTIVATION OF THYROTROPIN-RELEASING HORMONE (TRH)
    REDDING, TW
    SCHALLY, AV
    PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 1969, 131 (02): : 415 - &
12345