Regulatory mechanism of tyrosine hydroxylase activity

被引：67

作者：

Fujisawa, H ^{[1
]}

Okuno, S ^{[1
]}

机构：

[1] Shiga Med Ctr Res Inst, Moriyama 5248524, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 338卷 / 01期

关键词：

tvrosine hvdroxylase; enzyme activity regulation; protein phosphorylation; 14-3-3; protein; cAMP-dependent protein kinasc; Ca2+/calmodulin-dependent protein kinase; catecholamine; brain; oxygenase; cooperative phosphorylation;

D O I：

10.1016/j.bbrc.2005.07.183

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Activity of tyrosine hydroxylase is regulated by feedback inhibition and inactivation by catecholamines, and activation by protein phosphorylation. In this article, reaction mechanisms for the conversion of tyrosine hydroxylase to an inactive/stable form by catecholamines. and activation of tyrosine hydroxylase by phosphorylation Lit Ser-40 are discussed. Inactivation may be induced by sub-stoichiometric amounts of catecholamines, and activation by phosphorylation of Ser-4 0 may require phosphorylation of three or all four subunits of a tyrosine hydroxylase molecule. Cooperative phosphorylation Lit Ser-40 in the subunits is also discussed. (c) 2005 Elsevier Inc. All rights reserved.

引用

收藏

页码：271 / 276

页数：6

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