Regulatory mechanism of tyrosine hydroxylase activity

被引：67
作者：
Fujisawa, H [1 ]
Okuno, S [1 ]
机构：
[1] Shiga Med Ctr Res Inst, Moriyama 5248524, Japan
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 338卷 / 01期
关键词：
tvrosine hvdroxylase; enzyme activity regulation; protein phosphorylation; 14-3-3; protein; cAMP-dependent protein kinasc; Ca2+/calmodulin-dependent protein kinase; catecholamine; brain; oxygenase; cooperative phosphorylation;
D O I：
10.1016/j.bbrc.2005.07.183
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Activity of tyrosine hydroxylase is regulated by feedback inhibition and inactivation by catecholamines, and activation by protein phosphorylation. In this article, reaction mechanisms for the conversion of tyrosine hydroxylase to an inactive/stable form by catecholamines. and activation of tyrosine hydroxylase by phosphorylation Lit Ser-40 are discussed. Inactivation may be induced by sub-stoichiometric amounts of catecholamines, and activation by phosphorylation of Ser-4 0 may require phosphorylation of three or all four subunits of a tyrosine hydroxylase molecule. Cooperative phosphorylation Lit Ser-40 in the subunits is also discussed. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：271 / 276
页数：6
相关论文
共 50 条
[31]   Genetic diversity of tyrosine hydroxylase (TH) and dopamine β-hydroxylase (DBH) genes in cattle breeds [J].
Lelidett Lourenco-Jaramillo, Diana ;
Maria Sifuentes-Rincon, Ana ;
Manuel Parra-Bracamonte, Gaspar ;
Fabiola de la Rosa-Reyna, Xochitl ;
Segura-Cabrera, Aldo ;
Arellano-Vera, Williams .
GENETICS AND MOLECULAR BIOLOGY, 2012, 35 (02) :435-+
[32]   Increased hippocampal excitability and impaired spatial memory function in mice lacking VGLUT2 selectively in neurons defined by tyrosine hydroxylase promoter activity [J].
Nordenankar, Karin ;
Smith-Anttila, Casey J. A. ;
Schweizer, Nadine ;
Viereckel, Thomas ;
Birgner, Carolina ;
Mejia-Toiber, Jana ;
Morales, Marisela ;
Leao, Richardson N. ;
Wallen-Mackenzie, Asa .
BRAIN STRUCTURE & FUNCTION, 2015, 220 (04) :2171-2190
[33]   Adsorption and Bioactivity of Tyrosine Hydroxylase on Gold Surfaces and Nanoparticles [J].
Halskau, Oyvind ;
Volden, Sondre ;
Calvo, Ana C. ;
Martinez, Aurora ;
Glomm, Wilhelm R. .
PROTEIN AND PEPTIDE LETTERS, 2010, 17 (11) :1376-1382
[34]   Distributions of hypothalamic neuron populations coexpressing tyrosine hydroxylase and the vesicular GABA transporter in the mouse [J].
Negishi, Kenichiro ;
Payant, Mikayla A. ;
Schumacker, Kayla S. ;
Wittmann, Gabor ;
Butler, Rebecca M. ;
Lechan, Ronald M. ;
Steinbusch, Harry W. M. ;
Khan, Arshad M. ;
Chee, Melissa J. .
JOURNAL OF COMPARATIVE NEUROLOGY, 2020, 528 (11) :1833-1855
[35]   Simultaneous Identification of Tyrosine Hydroxylase and Choline Acetyltransferase Neurons [J].
Ihunwo, A. O. ;
Schliebs, R. .
JOURNAL OF ANIMAL AND VETERINARY ADVANCES, 2007, 6 (09) :1116-1119
[36]   MUTANT TORSINA INTERACTS WITH TYROSINE HYDROXYLASE IN CULTURED CELLS [J].
O'Farrell, C. A. ;
Martin, K. L. ;
Hutton, M. ;
Delatycki, M. B. ;
Cookson, M. R. ;
Lockhart, P. J. .
NEUROSCIENCE, 2009, 164 (03) :1127-1137
[37]   Differential Regulation of Tyrosine Hydroxylase by Continuous and Intermittent Hypoxia [J].
Raghuraman, Gayatri ;
Prabhakar, Nanduri R. ;
Kumar, Ganesh K. .
ARTERIAL CHEMORECEPTION: FROM MOLECULES TO SYSTEMS, 2012, 758 :381-385
[38]   Neuromelanin in substantia nigra neurons lacking tyrosine hydroxylase [J].
Grigoriev I.P. ;
Sukhorukova E.G. ;
Kolos E.A. ;
Korzhevskii D.E. .
Neuroscience and Behavioral Physiology, 2013, 43 (4) :461-463
[39]   IN-VIVO ACTIVITY OF TYROSINE-HYDROXYLASE IN RAT ADRENAL-GLANDS FOLLOWING ADMINISTRATION OF QUINPIROLE AND DOPAMINE [J].
KUJACIC, M ;
CARLSSON, A .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1995, 278 (01) :9-15
[40]   Differential and Interactive Effects of Ligand-Bound Progesterone Receptor A and B Isoforms on Tyrosine Hydroxylase Promoter Activity [J].
Jensik, P. J. ;
Arbogast, L. A. .
JOURNAL OF NEUROENDOCRINOLOGY, 2011, 23 (10) :915-925
12345