Regulatory mechanism of tyrosine hydroxylase activity

被引：66
作者：
Fujisawa, H [1 ]
Okuno, S [1 ]
机构：
[1] Shiga Med Ctr Res Inst, Moriyama 5248524, Japan
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 338卷 / 01期
关键词：
tvrosine hvdroxylase; enzyme activity regulation; protein phosphorylation; 14-3-3; protein; cAMP-dependent protein kinasc; Ca2+/calmodulin-dependent protein kinase; catecholamine; brain; oxygenase; cooperative phosphorylation;
D O I：
10.1016/j.bbrc.2005.07.183
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Activity of tyrosine hydroxylase is regulated by feedback inhibition and inactivation by catecholamines, and activation by protein phosphorylation. In this article, reaction mechanisms for the conversion of tyrosine hydroxylase to an inactive/stable form by catecholamines. and activation of tyrosine hydroxylase by phosphorylation Lit Ser-40 are discussed. Inactivation may be induced by sub-stoichiometric amounts of catecholamines, and activation by phosphorylation of Ser-4 0 may require phosphorylation of three or all four subunits of a tyrosine hydroxylase molecule. Cooperative phosphorylation Lit Ser-40 in the subunits is also discussed. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：271 / 276
页数：6
相关论文
共 50 条
  • [21] INHIBITORY EFFECT OF NEUROPEPTIDE-Y (NPY) ON THE IN-VITRO ACTIVITY OF TYROSINE-HYDROXYLASE
    CHENG, JT
    CHANG, CL
    TSAI, CL
    [J]. NEUROSCIENCE LETTERS, 1994, 167 (1-2) : 117 - 120
  • [22] Zinc antagonizes iron-regulation of tyrosine hydroxylase activity and dopamine production in Drosophila melanogaster
    Xiao, Guiran
    Zhao, Mengran
    Liu, Zhihua
    Du, Fan
    Zhou, Bing
    [J]. BMC BIOLOGY, 2021, 19 (01)
  • [23] Changes in Tyrosine Hydroxylase Activity and Dopamine Synthesis in the Nigrostriatal System of Mice in an Acute Model of Parkinson's Disease as a Manifestation of Neurodegeneration and Neuroplasticity
    Kolacheva, Anna
    Alekperova, Leyla
    Pavlova, Ekaterina
    Bannikova, Alyona
    Ugrumov, Michael V.
    [J]. BRAIN SCIENCES, 2022, 12 (06)
  • [24] The Sustained Phase of Tyrosine Hydroxylase Activation In vivo
    Ong, Lin Kooi
    Sominsky, Luba
    Dickson, Phillip W.
    Hodgson, Deborah M.
    Dunkley, Peter R.
    [J]. NEUROCHEMICAL RESEARCH, 2012, 37 (09) : 1938 - 1943
  • [25] CONVERSION OF TYROSINE-HYDROXYLASE TO STABLE AND INACTIVE FORM BY THE END-PRODUCTS
    OKUNO, S
    FUJISAWA, H
    [J]. JOURNAL OF NEUROCHEMISTRY, 1991, 57 (01) : 53 - 60
  • [26] The C886T Mutation in the Th Gene Reduces the Activity of Tyrosine Hydroxylase in the Mouse Brain
    Alsalloum, Ismail
    Moskaliuk, Vitalii S.
    Rakhov, Ilya A.
    Bazovkina, Daria V.
    Kulikov, Alexander V.
    [J]. BIOCHEMISTRY-MOSCOW, 2024, 89 (06) : 1024 - 1030
  • [27] GDNF abates serum deprivation-induced tyrosine hydroxylase Ser19 phosphorylation and activity
    Kobori, Nobuhide
    Moore, Anthony N.
    Dash, Pramod K.
    [J]. BRAIN RESEARCH, 2006, 1086 : 142 - 151
  • [28] Short-term Effects of Endothelins on Tyrosine Hydroxylase Activity and Expression in the Olfactory Bulb of Normotensive Rats
    Nabhen, Sabrina L.
    Perfume, Guadalupe
    Battistone, Maria A.
    Rossi, Andres
    Abramoff, Tamara
    Bianciotti, Liliana G.
    Vatta, Marcelo S.
    [J]. NEUROCHEMICAL RESEARCH, 2009, 34 (05) : 953 - 963
  • [29] In vitro effects of catecholamines and catecholestrogens on brain tyrosine hydroxylase activity and kinetics in the female catfish Heteropneustes fossilis
    Chaube, R
    Joy, KP
    [J]. JOURNAL OF NEUROENDOCRINOLOGY, 2003, 15 (03) : 273 - 279
  • [30] NT5DC2 affects the phosphorylation of tyrosine hydroxylase regulating its catalytic activity
    Nakashima, Akira
    Yamaguchi, Hisateru
    Kondo, Mii
    Furumura, Takahiro
    Kodani, Yu
    Kaneko, Yoko S.
    Kawata, Miho
    Nagasaki, Hiroshi
    Nagatsu, Toshiharu
    Ota, Akira
    [J]. JOURNAL OF NEURAL TRANSMISSION, 2020, 127 (12) : 1631 - 1640
12345