Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Children With Non-Hodgkin Lymphoma

被引:1
作者
Kara, Buket [1 ]
Gungorer, Vildan [2 ]
Akyurek, Fatma T. [3 ]
Koksal, Yavuz [1 ]
机构
[1] Selcuk Univ, Fac Med, Dept Pediat Hematol & Oncol, TR-42130 Konya, Turkey
[2] Selcuk Univ, Fac Med, Dept Pediat Rheumatol, Konya, Turkey
[3] Selcuk Univ, Fac Med, Dept Dermatol, Konya, Turkey
关键词
Stevens-Johnson syndrome; toxic epidermal necrolysis; non-Hodgkin lymphoma; children; LARGE-CELL LYMPHOMA; METHOTREXATE; CHEMOTHERAPY; ADOLESCENTS;
D O I
10.1097/MPH.0000000000001851
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The aim of this study is to evaluate the clinical and laboratory findings of pediatric patients with non-Hodgkin lymphoma (NHL) who developed Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Between 2006 and 2018, the medical records of child patients with NHL who developed SJS and TEN were reviewed retrospectively. SJS/TEN developed in 7 of 70 patients with NHL (10%). The pathologic subgroups of the patients with SJS/TEN were ALK-negative anaplastic large cell lymphoma (n: 3), Burkitt lymphoma (n: 2), lymphoblastic lymphoma (n: 1), and primary mediastinal B-cell lymphoma (n: 1). Five patients had TEN, 1 patient had SJS/TEN, and 1 patient developed only SJS. In 5 patients, both steroids and intravenous immunoglobulin were administered for treatment, and clinical improvement was achieved in 3 of these patients. Only steroid treatment was used for 1 patient, whereas for the other patient, intravenous immunoglobin was preferred. In addition, N-acetylcysteine treatment was administered for these 2 patients. Four patients with acute renal failure died, and it was found that SJS/TEN is observed more frequently in patients with NHL in which intensive treatment protocols with high-dose methotrexate are used more than with other childhood malignant diseases. Early diagnosis and administration of appropriate and supportive treatment approaches may improve the prognosis.
引用
收藏
页码:E310 / E314
页数:5
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