Dnmt3a silences hematopoietic stem cell self-renewal

被引：27

作者：

Trowbridge, Jennifer J. ^{[1
]}

Orkin, Stuart H.

机构：

[1] Childrens Hosp Boston, Dept Pediat Oncol, Dana Farber Canc Inst, Boston, MA 02115 USA

来源：

NATURE GENETICS | 2012年 / 44卷 / 01期

关键词：

NOVO DNA METHYLTRANSFERASE; MUTATIONS;

D O I：

10.1038/ng.1043

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

DNA methylation is an epigenetic mark stably directing gene expression throughout development. A new study uncovers a role for the DNA methyltransferase Dnmt3a in silencing self-renewal genes in hematopoietic stem cells (HSCs) to permit efficient hematopoietic differentiation.

引用

页码：13 / 14

页数：3

共 12 条

[1] Niche recycling through division-independent egress of hematopoietic stem cells [J].

Bhattacharya, Deepta ;

Czechowicz, Agnieszka ;

Ooi, A. G. Lisa ;

Rossi, Derrick J. ;

Bryder, David ;

Weissman, Irving L. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (12) :2837-2850

[2] DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction [J].

Broeske, Ann-Marie ;

Vockentanz, Lena ;

Kharazi, Shabnam ;

Huska, Matthew R. ;

Mancini, Elena ;

Scheller, Marina ;

Kuhl, Christiane ;

Enns, Andreas ;

Prinz, Marco ;

Jaenisch, Rudolf ;

Nerlov, Claus ;

Leutz, Achim ;

Andrade-Navarro, Miguel A. ;

Jacobsen, Sten Eirik W. ;

Rosenbauer, Frank .

NATURE GENETICS, 2009, 41 (11) :1207-1215

[3] Dnmt3a is essential for hematopoietic stem cell differentiation [J].

Challen, Grant A. ;

Sun, Deqiang ;

Jeong, Mira ;

Luo, Min ;

Jelinek, Jaroslav ;

Berg, Jonathan S. ;

Bock, Christoph ;

Vasanthakumar, Aparna ;

Gu, Hongcang ;

Xi, Yuanxin ;

Liang, Shoudan ;

Lu, Yue ;

Darlington, Gretchen J. ;

Meissner, Alexander ;

Issa, Jean-Pierre J. ;

Godley, Lucy A. ;

Li, Wei ;

Goodell, Margaret A. .

NATURE GENETICS, 2012, 44 (01) :23-U43

[4] Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression [J].

Gao, Qing ;

Steine, Eveline J. ;

Barrasa, M. Inmaculada ;

Hockemeyer, Dirk ;

Pawlak, Mathias ;

Fu, Dongdong ;

Reddy, Seshamma ;

Bell, George W. ;

Jaenisch, Rudolf .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (44) :18061-18066

[5] Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation [J].

Hervouet, Eric ;

Vallette, Francois M. ;

Cartron, Pierre-Francois .

EPIGENETICS, 2009, 4 (07) :487-499

[6] DNMT3A Mutations in Acute Myeloid Leukemia. [J].

Ley, Timothy J. ;

Ding, Li ;

Walter, Matthew J. ;

McLellan, Michael D. ;

Lamprecht, Tamara ;

Larson, David E. ;

Kandoth, Cyriac ;

Payton, Jacqueline E. ;

Baty, Jack ;

Welch, John ;

Harris, Christopher C. ;

Lichti, Cheryl F. ;

Townsend, R. Reid ;

Fulton, Robert S. ;

Dooling, David J. ;

Koboldt, Daniel C. ;

Schmidt, Heather ;

Zhang, Qunyuan ;

Osborne, John R. ;

Lin, Ling ;

O'Laughlin, Michelle ;

McMichael, Joshua F. ;

Delehaunty, Kim D. ;

McGrath, Sean D. ;

Fulton, Lucinda A. ;

Magrini, Vincent J. ;

Vickery, Tammi L. ;

Hundal, Jasreet ;

Cook, Lisa L. ;

Conyers, Joshua J. ;

Swift, Gary W. ;

Reed, Jerry P. ;

Alldredge, Patricia A. ;

Wylie, Todd ;

Walker, Jason ;

Kalicki, Joelle ;

Watson, Mark A. ;

Heath, Sharon ;

Shannon, William D. ;

Varghese, Nobish ;

Nagarajan, Rakesh ;

Westervelt, Peter ;

Tomasson, Michael H. ;

Link, Daniel C. ;

Graubert, Timothy A. ;

DiPersio, John F. ;

Mardis, Elaine R. ;

Wilson, Richard K. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (25) :2424-2433

[7] Jmjd3 and UTX Play a Demethylase-Independent Role in Chromatin Remodeling to Regulate T-Box Family Member-Dependent Gene Expression [J].

Miller, Sara A. ;

Mohn, Sarah E. ;

Weinmann, Amy S. .

MOLECULAR CELL, 2010, 40 (04) :594-605

[8] Exposing the DNA methylome iceberg [J].

Ndlovu, Matladi N. ;

Denis, Helene ;

Fuks, Francois .

TRENDS IN BIOCHEMICAL SCIENCES, 2011, 36 (07) :381-387

[9] De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells [J].

Tadokoro, Yuko ;

Ema, Hideo ;

Okano, Masaki ;

Li, En ;

Nakauchi, Hiromitsu .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (04) :715-722

[10] DNA Methyltransferase 1 Is Essential for and Uniquely Regulates Hematopoietic Stem and Progenitor Cells [J].

Trowbridge, Jennifer J. ;

Snow, Jonathan W. ;

Kim, Jonghwan ;

Orkin, Stuart H. .

CELL STEM CELL, 2009, 5 (04) :442-449

← 1 2 →