Effects of the serotonin and noradrenaline reuptake inhibitor (SNRI) milnacipran on marble burying behavior in mice

被引：17

作者：

Sugimoto, Yumi ^{[1
,2
]}

Tagawa, Noriko ^{[3
]}

Kobayashi, Yoshiharu ^{[3
]}

Hotta, Yoshihiro ^{[4
]}

Yamada, Jun ^{[1
,2
]}

机构：

[1] Yokohama Coll Pharm, Dept Clin Pharm, Pharmacol Lab, Totsuka Ku, Yokohama, Kanagawa 2450066, Japan

[2] Kobe Pharmaceut Univ, Dept Pharmacol, Kobe, Hyogo, Japan

[3] Kobe Pharmaceut Univ, Dept Med Biochem, Higashinada Ku, Kobe, Hyogo 6588558, Japan

[4] Kinjo Gakuin Univ Coll Pharm, Moriyama Ku, Nagoya, Aichi 4638521, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2007年 / 30卷 / 12期

关键词：

milacnipran; antidepressant; marble burying behavior; serotonin and noradrenaline reuptake inhibitor; fluvoxamine;

D O I：

10.1248/bpb.30.2399

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of milnacipran, a serotonin and noradrenaline reuptake inhibitor (SNRI) on the obsessive compulsive disorder (OCD) model, marble burying behavior, were investigated in mice. Milnacipran above the dosage of 10 mg/kg inhibited marble burying behavior significantly in mice as similar to fluvoxamine. Milnacipran inhibiting marble burying behavior did not affect locomotor activity. These results suggest that milnacipran can inhibit marble burying behavior and that milacipran may be useful for OCD therapy.

引用

页码：2399 / 2401

页数：3

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