Objectives. - To investigate whether Schumann resonance (SR) affects blood pressure (BP), heart rate (HR), and depression and, if so, whether the putative BP reactivity to SR (BPR-SR) is associated with health-related lifestyle (HLS), disease-related illnesses (DRI), and depression. Methods. - A sample of 56 adults in Urausu, Hokkaido, Japan, wore an ambulatory BP monitor, except for the time in the shower, for seven consecutive days. They completed the Geriatric Depression Scale-Short Form and a health survey questionnaire on HLS and DRI. Group mean differences and within-individual differences in systolic (S) and diastolic (D) BP, mean arterial pressure (MAP), double product (DP), and HR were, respectively, compared between normal and enhanced SR days, using Student's t-test, Correlations between BPR-SR and other characteristics (i.e. age, gender, HLS, DRI, subjective health, and depression) were analyzed, Using Pearson's product moment correlation. Results and discussion. - Group mean SBP, DBR MAP, and DP for enhanced SR days were lower than those for normal days (P = 0.0050,036). DRI was negatively associated with BPR-SR in SBP, DBP, MAP, and DP (P = 0,003-0.024). Suggesting it better health status for those who showed lower BP on enhanced SR days, HLS was negatively associated with BPR-SR in DBP and MAP (P = 0.016-0.029). Males showed higher BPR-SR in DBP and MAP than females (P = 0.004-0.016). Neither subjective health nor depression was significantly associated with BPR-SR. Future studies based on larger sample sizes are planned to see whether possible health effects can be generalized. (c) 2005 Elsevier SAS. All rights reserved.