Gellan gum capped silver nanoparticle dispersions and hydrogels: cytotoxicity and in vitro diffusion studies

被引：38

作者：

Dhar, S. ^{[2
,3
]}

Murawala, P. ^{[2
]}

Shiras, A. ^{[1
]}

Pokharkar, V. ^{[3
]}

Prasad, B. L. V. ^{[2
]}

机构：

[1] Natl Ctr Cell Sci, Pune 411007, Maharashtra, India

[2] Natl Chem Lab, Mat Chem Div, Pune 411008, Maharashtra, India

[3] Bharati Vidyapeeth Univ, Poona Coll Pharm, Pune 411038, Maharashtra, India

来源：

NANOSCALE | 2012年 / 4卷 / 02期

关键词：

ANTIMICROBIAL ACTIVITY; ANTIBACTERIAL ACTION; GOLD NANOPARTICLES; TOXICITY; NPS; NANOCOMPOSITES; PENETRATION; MATRIX; CELLS; SKIN;

D O I：

10.1039/c1nr10957j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The preparation of highly stable water dispersions of silver nanoparticles using the naturally available gellan gum as a reducing and capping agent is reported. Further, exploiting the gel formation characteristic of gellan gum silver nanoparticle incorporated gels have also been prepared. The optical properties, morphology, zeta potential and long-term stability of the synthesized silver nanoparticles were investigated. The superior stability of the gellan gum-silver nanoparticle dispersions against pH variation and electrolyte addition is revealed. Finally, we studied the cytotoxicity of AgNP dispersions in mouse embryonic fibroblast cells (NIH3T3) and also evaluated the in vitro diffusion of AgNP dispersions/gels across rat skin.

引用

页码：563 / 567

页数：5

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