The automatic image analysis of red blood cell deformability and blood flow in microchannels with an image-intensified high-speed video camera system

被引：0

作者：

Shimizu, T ^{[1
]}

Sekizuka, E ^{[1
]}

Oshio, C ^{[1
]}

Tsukada, K ^{[1
]}

Nagai, T ^{[1
]}

Hokari, R ^{[1
]}

Minamitani, H ^{[1
]}

机构：

[1] Keio Univ, Fac Sci & Technol, Inst Biomed Engn, Kohoku Ku, Yokohama, Kanagawa 2230061, Japan

来源：

PROCEEDINGS OF THE 20TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOL 20, PTS 1-6: BIOMEDICAL ENGINEERING TOWARDS THE YEAR 2000 AND BEYOND | 1998年 / 20卷

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

It is crucial in microcirculatory investigation to evaluate red blood cell (RBC) deformability. However, there are almost limited information and indirect method of analyses. We tried to measure RBC deformability automatically by a combination of a newly developed algorithm and recording of individual RBC images clearly with an image-intensified high-speed video camera system. The length and the diameter of individual RBCs were measured automatically for RBC velocity measurement. RBC deformability was calculated from the histogram of density at each pixel by our algorithm. To ensure reliability of this system we compared actual measurement with automatic analysis for RBC velocity and RBC deformability. Each correlation value (R-2=0.99) showed the validity of this system. In addition this system can shorten the time needed for measuring. We could confirm that the deformability of diabetic RBCs of HbAlc 12.1% was much more decreased compared with that of Hbalc 6.4%. The deformability of diabetic RBCs might depend on hyperglycemic degree of diabetic patients. In addition, The pentoxifylline improved the deformability of diabetic RBCs.

引用

页码：914 / 915

页数：2