Scutellarin inhibits translocation of protein kinase C in diabetic thoracic aorta of the rat

被引：18
|
作者：
Su, Yingxue [1 ]
Liu, Wei [1 ]
Ma, Li [1 ]
Liu, Xiaochang [1 ]
Liu, Zhaochun [1 ]
Zhu, Banghao [1 ]
机构：
[1] Sun Yat Sen Univ, Zhongshan Sch Med, Dept Pharmacol, Cardiac & Cerebral Vasc Res Ctr, Guangzhou 510080, Guangdong, Peoples R China
来源：
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2012年 / 39卷 / 02期
关键词：
protein kinase C; scutellarin; thoracic aortic smooth muscle cells; translocation; HIGH GLUCOSE; VASCULAR COMPLICATIONS; ACTIVATION; EXPRESSION; CELLS; DELTA; PATHOPHYSIOLOGY; RETINOPATHY; APOPTOSIS; ISOFORMS;
D O I：
10.1111/j.1440-1681.2011.05645.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. The aims of the present study were to explore the effects of: (i) scutellarin (Scu) on protein kinase C (PKC) translocation caused by diabetic conditions in diabetic rat thoracic aorta; and (ii) phorbol-12-myristate-13-acetate (PMA) treatment of cultured thoracic aortic smooth muscle cells.
引用
收藏
页码：136 / 140
页数：5
相关论文
共 50 条
  • [31] Protein kinase C-γ activation in the early streptozotocin diabetic rat lens
    Lin, Dingbo
    Harris, Richie
    Stutzman, Rachael
    Zampighi, Guido A.
    Davidson, Harriett
    Takemoto, Dolores J.
    CURRENT EYE RESEARCH, 2007, 32 (06) : 523 - 532
  • [32] Ionizing irradiation inhibits BKCa current in rat aorta smooth muscle cells via protein kinase C: implication to arterial hypertension development
    Kizub, I.
    Pavlova, O.
    Soloviev, A.
    FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2008, 22 : 62 - 62
  • [33] ENDOTHELIUM-DERIVED RELAXING FACTOR INHIBITS THE ENDOTHELIN-1-INDUCED INCREASE IN PROTEIN-KINASE-C ACTIVITY IN RAT AORTA
    LANG, D
    LEWIS, MJ
    BRITISH JOURNAL OF PHARMACOLOGY, 1991, 104 (01) : 139 - 144
  • [34] Isoflurane Inhibits Protein Kinase Cγ and Calcium/Calmodulin Dependent Protein Kinase II-α Translocation to Synaptic Membranes in Ischemic Mice Brains
    Shohei Matsumoto
    Michihiro Murozono
    Daisuke Nagaoka
    Shuhei Matsuoka
    Akiko Takeda
    Hideyuki Narita
    Seigo Watanabe
    Atsushi Isshiki
    Yasuo Watanabe
    Neurochemical Research, 2008, 33 : 2302 - 2309
  • [35] Isoflurane inhibits protein kinase cγ and calcium/calmodulin dependent protein kinase II-α translocation to synaptic membranes in ischemic mice brains
    Matsumoto, Shohei
    Murozono, Michihiro
    Nagaoka, Daisuke
    Matsuoka, Shuhei
    Takeda, Akiko
    Narita, Hideyuki
    Watanabe, Seigo
    Isshiki, Atsushi
    Watanabe, Yasuo
    NEUROCHEMICAL RESEARCH, 2008, 33 (11) : 2302 - 2309
  • [36] EFFECTS OF INSULIN ON THE TRANSLOCATION OF PROTEIN-KINASE C-THETA AND OTHER PROTEIN-KINASE-C ISOFORMS IN RAT SKELETAL-MUSCLES
    YAMADA, K
    AVIGNON, A
    STANDAERT, ML
    COOPER, DR
    SPENCER, B
    FARESE, RV
    BIOCHEMICAL JOURNAL, 1995, 308 : 177 - 180
  • [37] Effects of protein kinase C inhibitors on ethanol-induced contractions in isolated rat aorta
    Jover, T
    Altura, BT
    Altura, BM
    ALCOHOL, 1999, 18 (01) : 17 - 22
  • [38] PROTEIN-KINASE-C IS A MEDIATOR OF LIPOPOLYSACCHARIDE-INDUCED VASCULAR SUPPRESSION IN THE RAT AORTA
    MCKENNA, TM
    CLEGG, JM
    WILLIAMS, TJ
    SHOCK, 1994, 2 (02): : 84 - 89
  • [39] SUBSTRATES FOR PROTEIN-KINASE C IN A CELL FREE PREPARATION OF RAT AORTA SMOOTH MUSCLES
    NAKAKI, T
    WISE, BC
    CHUANG, DM
    LIFE SCIENCES, 1988, 42 (13) : 1315 - 1321
  • [40] CHARACTERIZATION OF PROTEIN-KINASE-C FROM AORTA
    DELL, KR
    SEVERSON, DL
    BIOPHYSICAL JOURNAL, 1986, 49 (02) : A66 - A66
12345