Thielavin B methyl ester: a cytotoxic benzoate trimer from an unidentified fungus (MSX 55526) from the Order Sordariales

被引：14

作者：

Ayers, Sloan ^{[1
]}

Ehrmann, Brandie M. ^{[1
]}

Adcock, Audrey F. ^{[2
]}

Kroll, David J. ^{[2
]}

Wani, Mansukh C. ^{[3
]}

Pearce, Cedric J. ^{[4
]}

Oberlies, Nicholas H. ^{[1
]}

机构：

[1] Univ N Carolina, Dept Chem & Biochem, Greensboro, NC 27402 USA

[2] N Carolina Cent Univ, Dept Pharmaceut Sci, BRITE, Durham, NC 27707 USA

[3] Res Triangle Inst, Nat Prod Lab, Res Triangle Pk, NC 27709 USA

[4] Mycosynthetix Inc, Hillsborough, NC 27278 USA

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 44期

基金：

美国国家卫生研究院;

关键词：

Fungi; Cytotoxicity; Benzoate; Thielavin; APPI; ATMOSPHERIC-PRESSURE PHOTOIONIZATION; MASS-SPECTROMETRY; CHEMICAL-IONIZATION; INHIBITORS; ELUCIDATION; SPECIATION;

D O I：

10.1016/j.tetlet.2011.08.125

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

As part of our ongoing investigation of filamentous fungi for anticancer leads, an active fungal extract was identified from the Mycosynthetix library (MSX 55526; from the Order Sordariales). Bioactivity-directed fractionation yielded the known ergosterol peroxide (2) and 5 alpha,8 alpha-epidioxyergosta-6,9(11),22-trien-3 beta-ol (3), and a new benzoate trimer, termed thielavin B methyl ester (1). The structure elucidation of 1 was facilitated by the use of HRMS coupled to an APPI (atmospheric pressure photoionization) source. Compound 1 proved to be moderately active against a panel of three cancer cell lines. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：5733 / 5735

页数：3

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