Chemical Detoxification of Organomercurials

被引：41

作者：

Banerjee, Mainak ^{[1
]}

Karri, Ramesh ^{[1
]}

Rawat, Kuber Singh ^{[2
,3
]}

Muthuvel, Karthick ^{[1
]}

Pathak, Biswarup ^{[2
,3
]}

Roy, Gouriprasanna ^{[1
]}

机构：

[1] Shiv Nadar Univ, Dept Chem, Sch Nat Sci, Gautam Buddha Nagar 201314, UP, India

[2] Indian Inst Technol, Discipline Chem, Indore, Madhya Pradesh, India

[3] Indian Inst Technol, Ctr Mat Sci & Engn, Indore, Madhya Pradesh, India

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 32期

关键词：

detoxification; mercury; organomercurials; selones; thiones; HYDROGEN-SULFIDE; MERCURY DETOXIFICATION; THIOREDOXIN REDUCTASE; SELENIUM; METHYLMERCURY; RESISTANCE; TOXICOLOGY; GLUTATHIONE; BRAIN; ACID;

D O I：

10.1002/anie.201504413

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Organomercurials including methylmercury are ubiquitous environmental pollutants and highly toxic to humans. Now it could be shown that N-methylimidazole based thiones/selones having an N-CH2CH2OH substituent are remarkably effective in detoxifying various organomercurials to produce less toxic HgE (E=S, Se) nanoparticles. Compounds lacking the N-CH2CH2OH substituent failed to produce HgE nanoparticles upon treatment with organomercurials, suggesting that this moiety plays a crucial role in the detoxification by facilitating the desulfurization and deselenization processes. This novel way of detoxifying organomercurials may lead to the discovery of new compounds to treat patients suffering from methylmercury poisoning.

引用

页码：9323 / 9327

页数：5

共 49 条

[1]

[Anonymous], ANGEW CHEM

[2] Vitamin C, glutathione, or lipoic acid did not decrease brain or kidney mercury in rats exposed to mercury vapor [J].