Nonenzymatic Sensor for Lactate Detection in Human Sweat

被引：108
作者：
Zaryanov, Nikolay V. [1 ]
Nikitina, Vita N. [1 ]
Karpova, Elena V. [1 ]
Karyakina, Elena E. [1 ]
Karyakin, Arkady A. [1 ]
机构：
[1] Moscow MV Lomonosov State Univ, Chem Fac, Moscow 119991, Russia
来源：
ANALYTICAL CHEMISTRY | 2017年 / 89卷 / 21期
基金：
俄罗斯科学基金会;
关键词：
ANAEROBIC THRESHOLD; BLOOD LACTATE; BORONIC ACIDS; OXIDASE; BIOSENSOR; ELECTRODE; SACCHARIDES; STABILITY; GLUCOSE; IMMOBILIZATION;
D O I：
10.1021/acs.analchem.7b03662
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
For noninvasive diagnostics of hypoxia, we propose the nonenzymatic sensor based on screen-printed structures with the working surface modified in course of electropolymerization of 3-aminophenylboronic acid (3-APBA) with imprinting of lactate. Impedimetric sensor allows lactate detection in the range from 3 mM to 100 mM with the detection limit of 1.5 mM; response time is 2-3 min. Sensor sensitivity remains unchanged within 6 months of storage unpacked in dry state at a room temperature, which is unachievable for enzyme based devices. Analysis of human sweat with poly(3-APBA) based sensor is possible due to (i) much higher lactate content compared to other polyols and (ii) high sensor selectivity (K-lactate(glucose) < 3 10(-2)). Successful detection of lactate in human sweat by means of the poly(3-APBA) based sensor has been confirmed using the highly specific reference method based on lactate oxidase enzyme (correlation coefficient r > 0.9). The attractive performance characteristics of poly(3-APBA) based enzyme-free sensors justify their future use for noninvasive clinical analysis and sports medicine.
引用
收藏
页码：11198 / 11202
页数：5
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