Rapid analysis of synthetic cannabinoids using a miniature mass spectrometer with ambient ionization capability

被引：64

作者：

Ma, Qiang ^{[1
,2
]}

Bai, Hua ^{[1
]}

Li, Wentao ^{[1
]}

Wang, Chao ^{[1
]}

Cooks, R. Graham ^{[3
,5
]}

Ouyang, Zheng ^{[2
,3
,4
,5
]}

机构：

[1] Chinese Acad Inspect & Quarantine, Beijing 100176, Peoples R China

[2] Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA

[3] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

[4] Purdue Univ, Dept Elect & Comp Engn, W Lafayette, IN 47907 USA

[5] Purdue Univ, Ctr Analyt Instrumentat Dev, W Lafayette, IN 47907 USA

来源：

TALANTA | 2015年 / 142卷

基金：

中国国家自然科学基金; 美国国家卫生研究院;

关键词：

Ambient ionization; Biofluids; Tandem mass spectrometry; Drug of abuse; Paper spray; Extraction spray; RECTILINEAR ION-TRAP; DESIGNER DRUGS; HERBAL BLENDS; PAPER SPRAY; ORAL FLUID; MS/MS METHOD; HUMAN URINE; OPEN-AIR; PART; CHROMATOGRAPHY;

D O I：

10.1016/j.talanta.2015.04.044

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Synthetic cannabinoids are an emerging class of drugs of abuse and are of a great concern for transport control and usage regulation. In this study, we have developed rapid analytical methods using a miniature mass spectrometer for the identification of synthetic cannabinoids, as the traces of bulk powders on surfaces or substances in blood and urine. Significantly simplified work flows were developed by employing two ambient ionization methods, the paper spray and extraction spray ionization. Using five synthetic cannabinoids as examples, a limit of detection of 2 ng was estimated for the detection of trace powders on a bench surface and limits of quantitation as good as 10 ng/mL were obtained for the analysis of blood and urine samples. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：190 / 196

页数：7

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