Acute Loading and Aging Effects on Myostatin Pathway Biomarkers in Human Skeletal Muscle After Three Sequential Bouts of Resistance Exercise

被引：39

作者：

Dalbo, Vincent J. ^{[2
]}

Roberts, Michael D. ^{[3
]}

Sunderland, Kyle L. ^{[1
]}

Poole, Chris N. ^{[1
]}

Stout, Jeff R. ^{[1
]}

Beck, Travis W. ^{[1
]}

Bemben, Mike ^{[1
]}

Kerksick, Chad M. ^{[1
]}

机构：

[1] Univ Oklahoma, Dept Hlth & Exercise Sci, Norman, OK 73019 USA

[2] Cent Queensland Univ, Inst Hlth & Social Sci Res, Fac Sci Engn & Hlth, Sch Med & Appl Sci, Rockhampton, Qld 4702, Australia

[3] Univ Missouri, Dept Biomed Sci, Columbia, MO USA

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2011年 / 66卷 / 08期

关键词：

Muscle; Molecular; Exercise; PCR; Resistance Training; GROWTH-FACTOR-BETA; MESSENGER-RNA EXPRESSION; MYOGENIC GENE-EXPRESSION; ECCENTRIC EXERCISE; OLDER MEN; SIGNALING PATHWAYS; PROLONGED ABSENCE; SELF-RENEWAL; ATROPHY; MASS;

D O I：

10.1093/gerona/glr091

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

To determine the influence of age and resistance exercise on myostatin pathway-related genes, younger (n = 10; 28 +/- 5 years) and older (n = 10; 68 +/- 6 years) men underwent four testing conditions (T1- T4). A baseline (T1) muscle sample was obtained, whereas the second and third biopsies were obtained 48 hours following the first and second training sessions (T2, T3), and a final biopsy was taken 24 hours following T3. The training sessions consisted of 3 sets of 10 repetitions (80% of one repetition maximum) on leg press, hack squat, and leg extension exercises. Follistatin (FST) messenger RNA was greater in older compared with younger men at T1 and T2 (p < .05). Follistatin-like 3 (FSTL3) messenger RNA was greater in older compared with younger men at T1 and T4 (p < .05). In older men, there was a significant decrease in myostatin (MSTN) messenger RNA at T4 (p < .05). Older men contained less active (Ser-425 phosphorylated) SMAD3 (p-SMAD3) protein than younger men at T3 and T4 (p <.05). Although it is well known that younger individuals possess a greater hypertrophic potential to resistance exercise, it appears that older individuals may paradoxically possess a more favorable resistance exercise response regarding myostatin pathway-related genes and a protein marker of pathway activity. Future research is warranted to examine the physiological significance of this age-dependent mechanism.

引用

页码：855 / 865

页数：11

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