Principal component analysis of genetic data

被引:215
作者
Reich, David [1 ]
Price, Alkes L. [1 ]
Patterson, Nick [2 ,3 ]
机构
[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA
[2] Broad Inst Harvard, Cambridge, MA 02142 USA
[3] MIT, Cambridge, MA 02142 USA
关键词
D O I
10.1038/ng0508-491
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Principal component analysis ( PCA) has been a useful tool for analysis of genetic data, particularly in studies of human migration. A new study finds evidence that the observed geographic gradients, traditionally thought to represent major historical migrations, may in fact have other interpretations.
引用
收藏
页码:491 / 492
页数:2
相关论文
共 13 条
  • [1] Cavalli-Sforza L.L., 1994, HIST GEOGRAPHY HUMAN
  • [2] Ancient DNA from the first European farmers in 7500-year-old Neolithic sites
    Haak, W
    Forster, P
    Bramanti, B
    Matsumura, S
    Brandt, G
    Tänzer, M
    Villems, R
    Renfrew, C
    Gronenborn, D
    Alt, KW
    Burger, J
    [J]. SCIENCE, 2005, 310 (5750) : 1016 - 1018
  • [3] Going the distance: human population genetics in a clinal world
    Handley, Lori J. Lawson
    Manica, Andrea
    Goudet, Jerome
    Balloux, Francois
    [J]. TRENDS IN GENETICS, 2007, 23 (09) : 432 - 439
  • [4] Worldwide human relationships inferred from genome-wide patterns of variation
    Li, Jun Z.
    Absher, Devin M.
    Tang, Hua
    Southwick, Audrey M.
    Casto, Amanda M.
    Ramachandran, Sohini
    Cann, Howard M.
    Barsh, Gregory S.
    Feldman, Marcus
    Cavalli-Sforza, Luigi L.
    Myers, Richard M.
    [J]. SCIENCE, 2008, 319 (5866) : 1100 - 1104
  • [5] Going east: New genetic and archaeological perspectives on the modern human colonization of Eurasia
    Mellars, Paul
    [J]. SCIENCE, 2006, 313 (5788) : 796 - 800
  • [6] SYNTHETIC MAPS OF HUMAN GENE-FREQUENCIES IN EUROPEANS
    MENOZZI, P
    PIAZZA, A
    CAVALLISFORZA, L
    [J]. SCIENCE, 1978, 201 (4358) : 786 - 792
  • [7] Interpreting principal component analyses of spatial population genetic variation
    Novembre, John
    Stephens, Matthew
    [J]. NATURE GENETICS, 2008, 40 (05) : 646 - 649
  • [8] Population structure and eigenanalysis
    Patterson, Nick
    Price, Alkes L.
    Reich, David
    [J]. PLOS GENETICS, 2006, 2 (12): : 2074 - 2093
  • [9] Tracing the origin and spread of agriculture in Europe
    Pinhasi, R
    Fort, J
    Ammerman, AJ
    [J]. PLOS BIOLOGY, 2005, 3 (12): : 2220 - 2228
  • [10] Principal components analysis corrects for stratification in genome-wide association studies
    Price, Alkes L.
    Patterson, Nick J.
    Plenge, Robert M.
    Weinblatt, Michael E.
    Shadick, Nancy A.
    Reich, David
    [J]. NATURE GENETICS, 2006, 38 (08) : 904 - 909