Epigenetic regulation of insulin-like growth factor binding protein-3 (IGFBP-3) in cancer

被引：19
作者：
Perks, Claire M. [1 ,2 ]
Holly, Jeff M. P. [1 ,2 ]
机构：
[1] Univ Bristol, Southmead Hosp, IGF, Sch Clin Sci, Bristol BS10 5NB, Avon, England
[2] Univ Bristol, Southmead Hosp, IGF, Metab Endocrinol Grp, Bristol BS10 5NB, Avon, England
来源：
JOURNAL OF CELL COMMUNICATION AND SIGNALING | 2015年 / 9卷 / 02期
关键词：
IGFBP-3; DNA methylation; Cancer; BREAST-CANCER; PROMOTER METHYLATION; DNA METHYLATION; EXPRESSION; INHIBITION; GENES; HYPERMETHYLATION; MODULATION; MICRORNAS; PROGNOSIS;
D O I：
10.1007/s12079-015-0294-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Epigenetics refers to heritable changes in gene expression that are independent of alterations in DNA sequence. It is now accepted that disruption of epigenetic mechanisms plays a key role in the pathogenesis of cancer: culminating in altered gene function and malignant cellular transformation. DNA methylation and histone modifications are the most widely studied changes but non-coding RNAs such as miRNAs are also considered part of the epigenetic machinery. The insulin-like growth factor (IGF) axis is composed of two ligands, IGF-I and -II, their receptors and six high affinity IGF binding proteins (IGFBPs). The IGF axis plays a key role in cancer development and progression. As IGFBP genes have consistently been identified among the most common to be aberrantly altered in tumours, this review will focus on epigenetic regulation of IGFBP-3 in cancer for which the majority of evidence has been obtained.
引用
收藏
页码：159 / 166
页数：8
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