Patterns of distant metastasis in Chinese women according to breast cancer subtypes

被引：24
作者：
Wu, San-Gang [1 ]
Sun, Jia-Yuan [2 ]
Yang, Li-Chao [3 ]
Tang, Li-Ying [4 ]
Wang, Xue [4 ]
Chen, Xue-Ting [4 ]
Liu, Gui-Hua [5 ]
Lin, Huan-Xin [2 ]
Lin, Qin [1 ]
He, Zhen-Yu [2 ]
机构：
[1] Xiamen Univ, Affiliated Hosp 1, Dept Radiat Oncol, Xiamen 361003, Peoples R China
[2] Sun Yat Sen Univ, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Canc Ctr,Dept Radiat Oncol, Guangzhou 510060, Guangdong, Peoples R China
[3] Xiamen Univ, Dept Basic Med Sci, Coll Med, Xiamen 361005, Peoples R China
[4] Xiamen Univ, Coll Med, Fujian Prov Key Lab Ophthalmol & Visual Sci, Eye Inst, Xiamen 361005, Peoples R China
[5] Xiamen Univ, Sch Pharmaceut Sci, Xiamen 361005, Peoples R China
来源：
ONCOTARGET | 2016年 / 7卷 / 30期
基金：
中国国家自然科学基金;
关键词：
breast cancer; breast cancer subtype; distant metastasis; patterns; MOLECULAR SUBTYPES; RECURRENCE; SITE; DISEASE; SURVIVAL; OUTCOMES; IMPACT;
D O I：
10.18632/oncotarget.10099
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To access possible relationships between breast cancer subtypes (BCS) and patterns of distant metastasis in advanced breast cancer. Breast cancer patients with distant metastasis at two academic centers from 2000-2015 were retrospectively reviewed. The breast cancer was classified into four subtypes: hormone receptor (HR) +/ human epidermal growth factor receptor 2 (HER2) - (i.e., estrogen receptor [ER] + and/or progesterone receptor [PR] +, HER2-); HR+/HER2+ (ER+ and/or PR+, HER2+), HR-/HER2+ (ER- and PR-, and HER2+); and HR-/HER2-(ER- and PR-, and HER2-). A total of 679 patients were identified. The distribution of the BCS was 39.9% (271/679), 23.7% (161/679), 16.8% (114/679), and 19.6% (133/679) in HR+/HER2-, HR+/HER2+, HR-/HER2+, and HR-/HER2-, respectively. Patients with HR+/HER2+ and HR-/HER2+ subtypes were prone to abdominal and pelvic metastasis, those with HR+/HER2- and HR+/HER2+ subtypes were prone to bone metastasis, while patients with the HR-/HER2-subtype were prone to lung/mediastinal and brain metastases. In patients with pleural, axillary and/or neck lymph node, and other distant soft tissue metastases, there was no significant difference in metastatic patterns among the BCS. There are different patterns of distant metastasis associated with different BCS. There should be a different focus in the postoperative follow-up and monitoring of breast cancer patients with different BCS.
引用
收藏
页码：47975 / 47984
页数：10
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[41]   Neighborhood change and distant metastasis at diagnosis of breast cancer [J].
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