Synthesis of new chiral 1,3-aminoalcohols derived from levoglucosenone and their application in asymmetric alkylations

被引：13

作者：

Zanardi, Maria M. ^{[1
]}

Suarez, Alejandra G. ^{[1
]}

机构：

[1] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, CONICET, Inst Quim Rosario, RA-2000 Rosario, Santa Fe, Argentina

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 24期

关键词：

Levoglucosenone; 1,3-Aminoalcohols; Chiral ligands; Asymmetric induction; BETA-AMINO ALCOHOLS; ENANTIOSELECTIVE ADDITION; STEREOSELECTIVE-SYNTHESIS; CONVENIENT SYNTHESIS; ORGANOZINC REAGENTS; DIETHYL ZINC; CELLULOSE; BENZALDEHYDE; DERIVATIVES; AUXILIARIES;

D O I：

10.1016/j.tetlet.2015.04.051

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have developed a simple procedure for the preparation of chiral 1,3-aminoalcohols using the biomass derivative levoglucosenone, as the chiral starting material. 1,3-aminoalcohols, bearing primary and tertiary amino groups, were tested as chiral catalysts in the asymmetric addition of diethyl zinc to benzaldehyde. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：3762 / 3765

页数：4

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