Use of a platelet-rich fibrin membrane to repair traumatic tympanic membrane perforations: a comparative study

被引：37
作者：
Gur, Ozer Erdem [1 ]
Ensari, Nuray [1 ]
Ozturk, Mehmet Turker [1 ]
Boztepe, Osman Fatih [2 ]
Gun, Taylan [3 ]
Selcuk, Omer Tarik [1 ]
Renda, Levent [1 ]
机构：
[1] Antalya Educ & Res Hosp, Dept ENT, Antalya, Turkey
[2] Antalya Med Pk Hosp, Dept ENT, Antalya, Turkey
[3] Bahcesehir Univ, Med Pk Hosp, Dept ENT, Fac Med, Ankara, Turkey
来源：
ACTA OTO-LARYNGOLOGICA | 2016年 / 136卷 / 10期
关键词：
Wound healing; thrombocyte concentrates; fibrin membrane; ear drum perforation; GROWTH-FACTOR; PLASMA;
D O I：
10.1080/00016489.2016.1183042
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Objectives: (1) To evaluate the effects of a platelet-rich fibrin (PRF) membrane in the repair of traumatic tympanic membrane (TM) perforations; and (2) to compare the use of a PRF membrane with the paper patch technique with regard to recovery rates, healing time, and correction of the mean air-bone gap.Methods: A randomized, prospective analysis was performed for 60 patients who were treated for traumatic TM perforations using one of the two methods. Closure rate, speed of healing, and hearing gain were compared between the PRF (Group 1) and paper patch (Group 2) groups.Results: Closure was obtained in 28 (93%) perforations in Group 1 and 25 (83%) perforations in Group 2 (p>0.05). On day 10, full closure of the TM was observed in 24 (80%) patients in Group 1 and 16 (53%) patients in Group 2 (p<0.05). The improvement in the mean air-bone gap was 14.1dB in Group 1 and 12.4dB in Group 2 on post-operative day 45 (p<0.05).Conclusions: In comparison with the paper patch method, PRF, a new method, provided more rapid healing with more successful audiological results, and with no requirement for a second procedure.
引用
收藏
页码：1017 / 1023
页数：7
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