Human T cell leukemia virus type 1 (HTLV-1) and oncogene or oncomiR addiction?

被引：0
作者：
Jeang, Kuan-Teh [1 ]
机构：
[1] NIAID, Mol Microbiol Lab, NIH, Bethesda, MD 20892 USA
来源：
ONCOTARGET | 2010年 / 1卷 / 06期
关键词：
HTLV; ATL; MicroRNAs; Leukemia; oncogene; 1ST HUMAN RETROVIRUS; TAX GENE; I PX; LYMPHOCYTES; MECHANISMS; EXPRESSION; MICRORNAS; DISCOVERY; DISEASE; PROTEIN;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The mechanism of HTLV-1 transformation of cells to Adult T cell leukemia (ATL) remains not fully understood. Currently, the viral Tax oncoprotein is known to be required to initiate transformation. Emerging evidence suggests that Tax is not needed to maintain the transformed ATL phenotype. Recent studies have shown that HTLV-1 transformed cells show deregulated expression of cellular microRNAs (miRNAs). Here we discuss the possibility that early ATL cells are Tax-oncogene-addicted while late ATL cells are oncogenic microRNA (oncomiR) - addicted. The potential utility of interrupting oncomiR addiction as a cancer treatment is broached.
引用
收藏
页码：453 / 456
页数：4
相关论文
共 33 条
  • [1] Deregulation of microRNA involved in hematopoiesis and the immune response in HTLV-I adult T-cell leukemia
    Bellon, Marcia
    Lepelletier, Yves
    Hermine, Olivier
    Nicot, Christophe
    [J]. BLOOD, 2009, 113 (20) : 4914 - 4917
  • [2] Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
    Calin, GA
    Dumitru, CD
    Shimizu, M
    Bichi, R
    Zupo, S
    Noch, E
    Aldler, H
    Rattan, S
    Keating, M
    Rai, K
    Rassenti, L
    Kipps, T
    Negrini, M
    Bullrich, F
    Croce, CM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (24) : 15524 - 15529
  • [3] Aneuploidy and cancer
    Chi, Ya-Hui
    Jeang, Kuan-Teh
    [J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 2007, 102 (03) : 531 - 538
  • [4] Causes and consequences of microRNA dysregulation in cancer
    Croce, Carlo M.
    [J]. NATURE REVIEWS GENETICS, 2009, 10 (10) : 704 - 714
  • [5] The discovery of the first human retrovirus: HTLV-1 and HTLV-2
    Gallo, RC
    [J]. RETROVIROLOGY, 2005, 2 (1)
  • [6] Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development
    Gironella, Meritxell
    Seux, Mylene
    Xie, Min-Jue
    Cano, Carla
    Tomasini, Richard
    Gommeaux, Julien
    Garcia, Stephane
    Nowak, Jonathan
    Yeung, Man Lung
    Jeang, Kuan-Teh
    Chaix, Amandine
    Fazli, Ladan
    Motoo, Yoshiharu
    Wang, Qing
    Rocchi, Palma
    Russo, Antonio
    Gleave, Martin
    Dagorn, Jean-Charles
    Iovanna, Juan L.
    Carrier, Alice
    Pebusque, Marie-Josephe
    Dusetti, Nelson J.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (41) : 16170 - 16175
  • [7] Molecular mechanisms of cellular transformation by HTLV-1 Tax
    Grassmann, R
    Aboud, M
    Jeang, KT
    [J]. ONCOGENE, 2005, 24 (39) : 5976 - 5985
  • [8] DEVELOPMENT OF LEUKEMIA IN MICE TRANSGENIC FOR THE TAX GENE OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I
    GROSSMAN, WJ
    KIMATA, JT
    WONG, FH
    ZUTTER, M
    LEY, TJ
    RATNER, L
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (04) : 1057 - 1061
  • [9] Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I
    Hasegawa, H
    Sawa, H
    Lewis, MJ
    Orba, Y
    Sheehy, N
    Yamamoto, Y
    Ichinohe, T
    Tsunetsugu-Yokota, Y
    Katano, H
    Takahashi, H
    Matsuda, J
    Sata, T
    Kurata, T
    Nagashima, K
    Hall, WW
    [J]. NATURE MEDICINE, 2006, 12 (04) : 466 - 472
  • [10] Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis
    Higuchi, Masaya
    Fujii, Masahiro
    [J]. RETROVIROLOGY, 2009, 6
1234