Biologic mesh is non-inferior to synthetic mesh in CDC class 1 & 2 open abdominal wall reconstruction

Background: Biologic mesh has historically been used in contaminated abdominal wall reconstructions (AWRs). No study has compared outcomes of biologic and synthetic in clean and clean-contaminated hernia ventral hernia repair. Methods: A prospective AWR database identified patients undergoing open, preperitoneal AWR with biologic mesh in CDC class 1 and 2 wounds. Using propensity score matching, a matched cohort of patients with synthetic mesh was created. The objective was to assess recurrence rates and postoperative complications. Results: Fifty-eight patients were matched in each group. Patient in the biologic group had higher rates of immunosuppression, history of transplantation, and inflammatory bowel disease (p < 0.05). Operative variables were comparable for biologic vs synthetic, including defect size (230.5 +/- 135.4 vs 268.7 +/- 194.5 cm(2), p = 0.62), but the synthetic mesh group had larger meshes placed (575.6 +/- 247.0 vs 898.8 +/- 246.0 cm(2) p < 0.0001). Wound infections (15.5% vs 8.9%, p = 0.28) were equivalent, and recurrence rates (1.7% vs 3.4%, p = 1.00) were similar on follow up (19.3 +/- 23.3 vs 23.3 +/- 29.7 months, p = 0.56). Conclusions: In matched, lower risk, complex AWR patients with large hernia defects, biologic and synthetic meshes have equal outcomes. (c) 2021 Elsevier Inc. All rights reserved.