FcγRs in Health and Disease

被引：124

作者：

Nimmerjahn, Falk ^{[1
]}

Ravetch, Jeffrey V. ^{[2
]}

机构：

[1] Univ Erlangen Nurnberg, Chair Genet, D-91054 Erlangen, Germany

[2] Rockefeller Univ, Lab Mol Genet & Immunol, New York, NY 10021 USA

来源：

NEGATIVE CO-RECEPTORS AND LIGANDS | 2011年 / 350卷

关键词：

C-REACTIVE PROTEIN; THYMUS-DERIVED LYMPHOCYTES; VIRUS TYPE-1 REPLICATION; ANTIINFLAMMATORY ACTIVITY; HUMAN IGG1; STREPTOCOCCUS-PNEUMONIAE; RECEPTOR-IIA; IN-VIVO; NEPHROTOXIC NEPHRITIS; SELECTIVE ENGAGEMENT;

D O I：

10.1007/82_2010_86

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Genetic defects affecting the humoral immune response and especially the production of antibodies of the immunoglobulin G (IgG) isotype result in a heightened susceptibility to infections. Studies over the last years have demonstrated the crucial role of Fc-receptors for IgG (Fc gamma Rs) widely expressed on innate immune effector cells in mediating the protective function of lgG. During the last years, additional ligands interacting with Fc gamma Rs as well as additional receptors binding to IgG glycosylation variants have been identified. In this review, we discuss how the interaction of these different ligands with classical and novel Fc gamma-receptors influences the immune response and which strategies microorganisms have developed to prevent them.

引用

页码：105 / 125

页数：21

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