Dissolution performance of acyclovir released from layered double hydroxide clays prepared via spray-drying and lyophilization techniques

被引：4

作者：

Britto Aguilera, Cindy Siqueira ^{[1
]}

Barreto Barros Silva, Laysa Creusa Paes ^{[1
]}

Yun, Adriana Eun He Koo ^{[1
]}

de Alencar Danda, Lucas Jose ^{[1
]}

Moreira Domingues de Sousa, Andre Luiz ^{[1
]}

Ribeiro Timoteo, Taysa Renata ^{[1
]}

Roca Soares, Monica Felts de La ^{[1
]}

Rolim, Larissa Araujo ^{[1
]}

Ferreira da Silva, Rosali Maria ^{[1
]}

Rolim Neto, Pedro Jose ^{[1
]}

机构：

[1] Univ Fed Pernambuco, Dept Pharmaceut Sci, Recife, PE, Brazil

来源：

MATERIALS LETTERS | 2022年 / 311卷

关键词：

Controlled release; Layered double hydroxide; Spray-drying; Lyophilization;

D O I：

10.1016/j.matlet.2021.131607

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Our aim was to investigate the impact of spray-drying and lyophilization techniques on the dissolution profile of acyclovir combined with a MgAl-Cl layered double hydroxide clays. Powder X-Ray Diffraction and Scanning Electron Microscopy were performed to characterize the solid state of the systems. Dissolution was performed under sink conditions in pH 6.8 buffer. Diffractograms showed that spray-dried systems had a lower degree of crystallinity compared to lyophilized ones, while photomicrographs evidenced the drug adhered to the clay surface, revealing spherical and splintered shapes for spray-dried and lyophilized systems, respectively. Claydrug systems prepared with 2:1 M proportion via spray-drying were able to slow acyclovir release rate, compared to crystalline drug. Spray-dried systems showed a distinct kinetic release mechanism compared to lyophilized systems and crystalline acyclovir.

引用

页数：4

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