Granulomatous hepatitis in cattle caused by Mycobacterium avium subsp. paratuberculosis

被引：0

作者：

Rodrigues, A. B. F. ^{[1
]}

Ristow, P. ^{[2
]}

Santos, A. S. O. ^{[3
]}

Lilenbaum, W. ^{[4
]}

Fonseca, L. S. ^{[5
]}

Carvalho, C. B. ^{[1
]}

Carvalho, E. C. Q. ^{[1
]}

机构：

[1] Univ Estadual Norte Fluminense, BR-28013602 Campos Dos Goytacazes, RJ, Brazil

[2] CPqGM FIOCRUZ, Rio De Janeiro, Brazil

[3] Inst Fed Educ Para, Belem, Para, Brazil

[4] Univ Fed Fluminense, Niteroi, RJ, Brazil

[5] Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil

来源：

ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA | 2010年 / 62卷 / 06期

关键词：

bovine; paratuberculosis; hepatitis; histopathology; JOHNES-DISEASE; DIAGNOSIS; CULTURE; BRAZIL;

D O I：

10.1590/S0102-09352010000600029

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Samples from intestines, liver, and lymph nodes were collected from a dairy steer with clinical suspicion of paratuberculosis. The samples were processed for histologic examination with hematoxylin-eosin and Zihel-Neelsen (ZN) staining for the detection of acid-fast bacilli (AFB), and submitted to immunohistochemistry (IHC). Macroscopic changes were observed in the small intestines, with thickening and corrugation of the mucosa. The main microscopic changes were found in small intestines, lymph vessels in the mesentery, and mesenteric lymph nodes characterized by enteritis, lymphangiectasia, and lymphadenitis. Liver presented with granulomatous hepatitis, an uncommon histopathological feature for paratuberculosis. The clinical features associated with positive culture of Mycobacterium avium subsp. paratuberculosis and detection of AFB by ZN and IHC in the cytoplasm of macrophages (epithelioid) in the intestinal mucosa and submucosa, lymph nodes, and liver were important to confirm the diagnosis of paratuberculosis.

引用

页码：1495 / 1498

页数：4