Blood Compatibility of Oxidized Bacterial Cellulose/Silk Fibroin Composite Membrane

In this work, the oxidized bacterial cellulose (BC) was modified by silk fibroin (SF) to improve its blood compatibility. The oxidized BC pellicles were added to the aqueous silk fibroin solution containing crosslinking agents at room temperature for different times to obtain the composite membranes. The structure of the new composites membranes were evaluated by X-ray photoelectron spectroscopy (XPS). The results showed that silk fibroins were successfully fabricated on the oxidized bacterial cellulose (OBC) membranes surfaces, and the analysis on the quantity of the elements exhibits that the atom percentage of nitrogen reaches its maximum value at 24 h. The platelet adhesion, hemolytic test and protein adsorption results exhibited that the OBC/SF had significantly excellent blood compatibility featured by lower platelet adhesion and protein adsorption without causing hemolysis. This work provides a simple approach to fabricate composite biomaterials which exhibit wide biomedical application prospects.