Impregnation of Ibuprofen into Polycaprolactone Using Supercritical Carbon Dioxide

被引：32
作者：
Yoganathan, Roshan [1 ]
Mammucari, Raffaella [1 ]
Foster, Neil R. [1 ]
机构：
[1] Univ New S Wales, Sch Chem Sci & Engn, Supercrit Fluids Res Grp, Sydney, NSW 2052, Australia
来源：
INTERNATIONAL CONFERENCE ON HIGH PRESSURE SCIENCE AND TECHNOLOGY, JOINT AIRAPT-22 AND HPCJ-50 | 2010年 / 215卷
关键词：
RING-OPENING POLYMERIZATION; EPSILON-CAPROLACTONE; RELEASE;
D O I：
10.1088/1742-6596/215/1/012087
中图分类号：
TH7 [仪器、仪表];
学科分类号：
0804 ; 080401 ; 081102 ;
摘要：
Polycaprolactone (PCL) is a Food and Drug Administration (FDA) approved biodegradable polyester used in tissue engineering applications. Ibuprofen is an anti-inammatory drug which has good solubility in supercritical CO2 (SCCO2). The solubility of CO2 in PCL allows for the impregnation of CO2-soluble therapeutic agents into the polymer via a supercritical fluid (SCF) process. Polymers impregnated with bio-active compounds are highly desired for medical implants and controlled drug delivery. In this study, the use of CO2 to impregnate PCL with ibuprofen was investigated. The effect of operating conditions on the impregnation of ibuprofen into PCL was investigated over two pressure and two temperature levels, 150bar and 200bar, 35 degrees C and 40 degrees C, respectively. Polycaprolactone with drug-loadings as high as 27% w/w were obtained. Impregnated samples exhibited controlled drug release profiles over several days.
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