Tyrosine kinase signaling pathways in neutrophils

被引:61
作者
Futosi, Krisztina [1 ,2 ,3 ]
Mocsai, Attila [1 ,2 ,3 ]
机构
[1] Semmelweis Univ, Sch Med, Dept Physiol, Budapest, Hungary
[2] Hungarian Acad Sci, MTA SE Lendulet Inflammat Physiol Res Grp, Budapest, Hungary
[3] Semmelweis Univ, Budapest, Hungary
基金
英国惠康基金;
关键词
neutrophils; Fc-receptors; integrins; protein kinases/phosphatases; inflammation; signal transduction; SRC-FAMILY KINASES; FC-GAMMA-RIII; LYN-DEFICIENT MICE; LEUKOCYTE ADHESION; INTEGRIN ACTIVATION; RESPIRATORY BURST; IMMUNE-COMPLEXES; INNATE IMMUNITY; REGULATE NEUTROPHIL; MURINE NEUTROPHILS;
D O I
10.1111/imr.12455
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Neutrophils play a critical role in antimicrobial host defense, but their improper activation also contributes to inflammation-induced tissue damage. Therefore, understanding neutrophil biology is important for the understanding, diagnosis, and therapy of both infectious and inflammatory diseases. Neutrophils express a large number of cell-surface receptors that sense extracellular cues and trigger various functional responses through complex intracellular signaling pathways. During the last several years, we and others have shown that tyrosine kinases play a critical role in those processes. In particular, Src-family and Syk tyrosine kinases couple Fc-receptors and adhesion receptors (integrins and selectins) to various neutrophil effector functions. This pathway shows surprising similarity to lymphocyte antigen receptor signaling and involves various other enzymes (e.g. PLC gamma 2), exchange factors (e.g. Vav-family members) and adapter proteins (such as ITAM-containing adapters, SLP-76, and CARD9). Those mediators trigger various antimicrobial functions and play a critical role in coordinating the inflammatory response through the release of inflammatory mediators, such as chemokines and LTB4. Interestingly, however, tyrosine kinases have a limited direct role in the migration of neutrophils to the site of inflammation. Here, we review the role of tyrosine kinase signaling pathways in neutrophils and how those pathways contribute to neutrophil activation in health and disease.
引用
收藏
页码:121 / 139
页数:19
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