Protective effect of baicalein on renal ischemia/reperfusion injury in the rat

被引：24

作者：

Wu, Kefei ^{[1
]}

Li, Hongyan ^{[2
]}

Tian, Jianwei ^{[3
]}

Lei, Wenjing ^{[3
]}

机构：

[1] Shantou Univ, Dept Nephrol, Coll Med, Affiliated Hosp 1, Shantou, Peoples R China

[2] Southern Med Univ, Huadu Dist Peoples Hosp, Ctr Kidney Dis, Guangzhou 510800, Guangdong, Peoples R China

[3] Southern Med Univ, Inst Nephrol Dis, Nanfang Hosp, Guangzhou 510800, Guangdong, Peoples R China

来源：

RENAL FAILURE | 2015年 / 37卷 / 02期

关键词：

Baicalein; inflammatory effects; ischemia-reperfusion injury; kidney injury; oxidative stress; OXIDATION PROTEIN PRODUCTS; ACUTE KIDNEY INJURY; INDUCED APOPTOSIS; FAILURE; INHIBITION; ACTIVATION; PEROXIDE; PATHWAYS; CELLS; MODEL;

D O I：

10.3109/0886022X.2014.991999

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To investigate the protective effect and the mechanism of baicalein (Bai) in rats with renal ischemia-reperfusion injury (RIRI). Methods: Twenty-four male Sprague-Dawley rats were divided into three groups: sham, IR, and IR + Bai. Bai was administered by tail vein injection (30 mg/kg) 30 min before reperfusion in the IR + Bai group. The IR group and sham group received saline vehicle via the intravenous route. Results: Rats that underwent RIRI exhibited renal functional impairment, histological changes, significantly increased advanced oxidation protein product (AOPP) and malondialdehyde (MDA) levels (p < 0.01), and ICAM-1 and MCP-1 protein and mRNA expression were significantly upregulated (p < 0.01). Administration of Bai reduced AOPP and MDA levels, significantly inhibited expression of inflammatory factors (p < 0.05), and markedly improved renal function. Conclusion: Bai promotes the recovery of renal function in established acute RIRI, and alleviates kidney injury in a rat model.

引用

页码：285 / 291

页数：7

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