Antibiofilm activity of propolis extract on Fusarium species from onychomycosis

被引：32

作者：

Galletti, Juliana ^{[1
]}

Tobaldini-Valerio, Flavia K. ^{[1
,2
]}

Silva, Sonia ^{[2
]}

Kioshima, Erika Seki ^{[1
]}

Trierveiler-Pereira, Larissa ^{[1
]}

Bruschi, Marcos ^{[3
]}

Negri, Melyssa ^{[1
]}

Estivalet Svidzinski, Terezinha Inez ^{[1
]}

机构：

[1] Univ Estadual Maringa, Dept Analises Clin & Biomed, Lab Med Mycol, Ave Colombo 5790, BR-87020900 Maringa, PR, Brazil

[2] Univ Minho, CEB Ctr Biol Engn, Braga, Portugal

[3] Univ Estadual Maringa, Dept Pharm, Lab Res & Dev Drug Delivery Syst, BR-87020900 Maringa, Parana, Brazil

来源：

FUTURE MICROBIOLOGY | 2017年 / 12卷 / 14期

关键词：

antifungal; fusariosis; paronychia; treatment; ungueal mycosis; BIOFILMS; CANDIDA; SPP; MODEL;

D O I：

10.2217/fmb-2017-0052

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aim: The present study evaluated the capacity of three species of Fusarium isolated from onychomycosis to form biofilms and the antibiofilm effect of propolis extract on these biofilms. Materials & methods: The biofilms and antibiofilm effects were evaluated by quantifying the colony-forming units, mitochondrial metabolic activity assays, total biomass by crystal violet staining and scanning electron microscopy. Results: Propolis extract demonstrated significant antibiofilm efficiency on Fusarium spp. isolates and reduced F. solani, F. oxysporum and F. subglutinans mature biofilms. Conclusion: Propolis extract can be an alternative topical treatment of onychomycosis caused by Fusarium spp.

引用

页码：1311 / 1321

页数：11

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