Cytidine deaminase 2 is required for VLRB antibody gene assembly in lampreys

被引：23
作者：
Morimoto, Ryo [1 ]
O'Meara, Connor P. [1 ]
Holland, Stephen J. [1 ]
Trancoso, Ines [1 ]
Souissi, Ahmed [2 ]
Schorpp, Michael [1 ]
Vassaux, Daniele [2 ]
Iwanami, Norimasa [1 ,3 ]
Giorgetti, Orlando B. [1 ]
Evanno, Guillaume [2 ]
Boehm, Thomas [1 ]
机构：
[1] Max Planck Inst Immunobiol & Epigenet, Dept Dev Immunol, D-79108 Freiburg, Germany
[2] Agrocampus Ouest, INRAE, Ecol & Ecosyst Hlth, ESE, F-35042 Rennes, France
[3] Natl Ctr Geriatr & Gerontol, Dept Regenerat Med, Obu, Japan
来源：
SCIENCE IMMUNOLOGY | 2020年 / 5卷 / 45期
基金：
欧洲研究理事会;
关键词：
IMMUNE-SYSTEM; EVOLUTION; IMMUNOGLOBULIN; RECOMBINATION; ANTIGEN; RECEPTORS; DIVERSIFICATION; RECOGNITION; CELLS; AID;
D O I：
10.1126/sciimmunol.aba0925
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The antibodies of jawless vertebrates consist of leucine-rich repeat arrays encoded by somatically assembled VLRB genes. It is unknown how the incomplete germline VLRB loci are converted into functional antibody genes during B lymphocyte development in lampreys. In Lampetra planeri larvae lacking the cytidine deaminase CDA2 gene, VLRB assembly fails, whereas the T lineage-associated VLRA and VLRC antigen receptor gene assemblies occur normally. Thus, CDA2 acts in a B cell lineage-specific fashion to support the somatic diversification of VLRB antibody genes. CDA2 is closely related to activation-induced cytidine deaminase (AID), which is essential for the elaboration of immunoglobulin gene repertoires in jawed vertebrates. Our results thus identify a convergent mechanism of antigen receptor gene assembly and diversification that independently evolved in the two sister branches of vertebrates.
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页数：9
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