Effects of gonadotropin-releasing hormone agonists on uterine volume and vasculature and on the immunohistochemical expression of basic fibroblast growth factor (bFGF) in uterine leiomyomas

被引：20
作者：
Di Lieto, A
De Falco, M
Staibano, S
Iannotti, F
Scaramellino, M
Salvatore, G
Mansueto, G
Granata, P
Pontillo, M
Pollio, F
De Rosa, G
机构：
[1] Univ Naples Federico II, Dept Obstet Gynaecol & Urol Sci & Reprod Med, Naples, Italy
[2] Univ Naples Federico II, Dept Biomorphol & Funct Sci, Naples, Italy
来源：
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY | 2003年 / 22卷 / 04期
关键词：
uterine leiomyomas; GnRH analogs; uterine volume changes; bFGF; immunohistochemistry; blood vessels;
D O I：
10.1097/01.PGP.0000070849.25718.73
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
We investigated the effect of the GnRH agonist (GnRH-a) on the uterine volume and on the immunohistochemical expression of basic fibroblast growth factor (bFGF) and the vasculature of leiomyomas. Twenty-five women were treated with leuprorelin acetate for 3 months; 46 untreated patients were enrolled as a control group. The uterine volume was measured by ultrasonography. After myomectomy or hysterectomy, the immunoexpression of bFGF and the endothelial marker, CD34, was studied and compared in treated and untreated leiomyomas. Uterine volume decreased after therapy. The number of cells expressing bFGF and the vascularity were diminished in treated leiomyomas. Reduction in the blood supply might be responsible, in part, for uterine-volume shrinkage after GnRH-a therapy.
引用
收藏
页码：353 / 358
页数：6
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