Early hypoxemia burden is strongly associated with severe intracranial hemorrhage in preterm infants

被引：34

作者：

Vesoulis, Zachary A. ^{[1
]}

Bank, Rachel L. ^{[1
]}

Lake, Doug ^{[2
]}

Wallman-Stokes, Aaron ^{[3
]}

Sahni, Rakesh ^{[3
]}

Moorman, J. Randall ^{[2
]}

Isler, Joseph R. ^{[3
]}

Fairchild, Karen D. ^{[4
]}

Mathur, Amit M. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Pediat, Div Newborn Med, St Louis, MO 63110 USA

[2] Univ Virginia, Dept Med, Charlottesville, VA USA

[3] Columbia Univ, Dept Pediat, New York, NY 10027 USA

[4] Univ Virginia, Dept Pediat, Charlottesville, VA USA

来源：

JOURNAL OF PERINATOLOGY | 2019年 / 39卷 / 01期

基金：

美国国家卫生研究院;

关键词：

BIRTH-WEIGHT INFANTS; CEREBRAL-BLOOD-FLOW; OXYGEN-SATURATION; GERMINAL MATRIX; INTRAVENTRICULAR HEMORRHAGE; DEATH; AUTOREGULATION; VALIDATION; DISABILITY; OUTCOMES;

D O I：

10.1038/s41372-018-0236-2

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objectives: The objective of this study was to define the association between the burden of severe hypoxemia (SpO(2) <= 70%) in the first week of life and development of severe ICH (grade III/IV) in preterm infants. Study design: Infants born at <32 weeks or weighing <1500 g underwent prospective SpO(2) recording from birth through 7 days. Severe hypoxemia burden was calculated as the percentage of the error-corrected recording where SpO(2) <= 70%. Binary logistic regression was used to model the relationship between hypoxemia burden and severe ICH. Results: A total of 163.3 million valid SpO(2) data points were collected from 645 infants with mean EGA = 27.7 +/- 2.6 weeks, BW = 1005 +/- 291 g; 38/645 (6%) developed severe ICH. There was a greater mean hypoxemia burden for infants with severe ICH (3%) compared to those without (0.1%) and remained significant when controlling for multiple confounding factors. Conclusion: The severe hypoxemia burden in the first week of life is strongly associated with severe ICH.

引用

页码：48 / 53

页数：6

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