The Role of GPR15 Function in Blood and Vasculature

被引：8
作者：
Bauer, Mario [1 ]
机构：
[1] UFZ Helmholtz Ctr Environm Res, Dept Environm Immunol, D-04318 Leipzig, Germany
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 19期
关键词：
GPR15; C10orf99; thrombomodulin; lymphocyte; blood; endothelial cell; vasculature; FACTOR-LIKE REGION; THROMBOMODULIN; EXPRESSION; ENDOCYTOSIS; ACTIVATION;
D O I：
10.3390/ijms221910824
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Since the first prominent description of the orphan G protein-coupled receptor 15 (GPR15) on lymphocytes as a co-receptor for the human immunodeficiency virus (HIV) type 1 and 2 and the first report about the GPR15-triggered cytoprotective effect on vascular endothelial cells by recombinant human thrombomodulin, several decades passed before the GPR15 has been recently deorphanized. Because of new findings on GPR15, this review will summarize the consequences of GPR15 signaling considering the variety of GPR15-expressing cell types and of GPR15 ligands, with a focus on blood and vasculature.
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页数：12
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